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Lactobacillus acidophilus (NCFM)
A lactic acid bacterium, strain NCFM. It is in one of our formulas, Digestion & microbiome, and it carries no authorised EU health claim. What it does have is a place on EFSA's safety list for microorganisms used in food, which is a different thing, and we keep the two apart.
WHAT WE ARE ALLOWED TO SAY
No authorised claim. A safety status instead.
There is no authorised health claim for Lactobacillus acidophilus on the EU register (Reg. 432/2012), so there is no wording to quote here, and we are not going to write a sentence that sounds like one. What the species does have is a place on EFSA's QPS list, the qualified presumption of safety for microorganisms used in food. That tells you it is presumed safe for healthy people, not for everyone (see who should not take it below). It does not tell you what it does for you.There is no authorised health claim for Lactobacillus acidophilus on the EU register (Reg. 432/2012). What it has is a place on EFSA's QPS safety list, which is not a claim.
In Digestion & microbiome, the only authorised claim that applies at the formula's doses belongs to zinc, not to the bacteria. Our file also describes how this species works: it makes lactic acid, attaches to the gut lining, competes there with pathogens for space, produces substances that act against them, interacts with the immune tissue of the gut and breaks down lactose in fermented dairy. None of that is an authorised claim, so you will not read it here as a promise.
WHY STRAIN NCFM
No salt to choose. A strain instead.
Bacteria do not come in chemical forms, so there is no oxide or citrate to weigh up here, and our file records none. It is used as it comes, a standardised strain. Ours is NCFM, the strain named in the two trials on our dose record, and the species sits on EFSA's QPS safety list. The strain is not a claim argument, and we do not use it as one.
A probiotic that turns sugars into lactic acid. Our file records it attaching to the gut lining, where it competes with pathogens for space. It leaves the body with the stool after passing through the gut, and our file has no figure for how much of it is absorbed.
Our file marks a dairy origin as possible, based on the typical commercial forms of strains like this one. So milk allergy, lactose intolerance and a vegan diet are on its warning list. Vegan-friendly strains exist if certified, but none is recorded for ours.
Our file puts the onset at one to two weeks, and records the bacteria as viable for 24 – 48 hours on their way through. That fits a base formula taken every morning and held for eight weeks, not a dose you would expect to feel the same day.
Our file on this strain is still a short one, and it says so: deeper research is pending. It has the mechanism, the safety status and one dose record, but no supplier grade, no confirmed dairy-free origin and no figure for how much of it survives the stomach. Until it does, treat the strain in our formula as possibly milk-derived, and read the allergen on the label if you are allergic to milk or cannot take lactose.Our file on this strain is still a short one. No supplier grade or dairy-free origin is on record yet, so treat it as possibly milk-derived and read the label.
WHERE IT APPEARS
One of the twenty-nine carries it.
It sits first in Digestion & microbiome, next to Bifidobacterium lactis, pasteurised Akkermansia, inulin, GOS and zinc, taken 15 – 30 minutes before breakfast, on an empty stomach so that more of it gets past the stomach acid. At 5 billion CFU it sits at the bottom of the 5 – 20 billion CFU a day used in the NCFM trials named in our file, and above the 1 billion CFU a day on our dose record.
THE CEILING
No upper limit has been set.
EFSA has not set a tolerable upper intake level for L. acidophilus, and its QPS listing comes without a number to count against, so there is no ceiling to draw here. Bacteria are counted in colony-forming units (CFU), not milligrams. Our file records 1 billion CFU once a day as the recommended dose for adults, and the NCFM trials it names used 5 – 20 billion CFU a day. The formula carries 5 billion.EFSA has not set an upper intake level for L. acidophilus. Our file records 1 billion CFU a day for adults; the NCFM trials used 5 – 20 billion. The formula carries 5 billion.
Our library records this strain in colony-forming units: 1 billion CFU a day on our dose record, 5 billion in Digestion & microbiome. No other VION formula carries it today, so there is nothing to add it to.
The formula is taken for at least 8 weeks, with no forced break, and your digestive symptoms are reassessed at 8 weeks. If SIBO is diagnosed, the formula comes out and a different one takes its slot.
Small intestinal bacterial overgrowth (SIBO) or severe immunosuppression: the formula that carries it is not for either. Ask a doctor first if you are immunocompromised, a cancer patient on chemotherapy, or have a central venous catheter. Not for milk allergy or lactose intolerance, as our file records a possible dairy origin. It is marked as not suitable for a vegan diet. And the usual three: do not exceed the daily dose, it does not replace a varied and balanced diet, and keep it out of reach of young children.
WHAT IT REACTS WITH
No documented pairs yet. Two fibres, one allergen.
L. acidophilus is one of the 140 ingredients in our library, so it has 139 possible partners. None of them is among the 443 pairs we have documented so far, and no medicine is on file against it either. What we do have is a note in another ingredient's file, and an allergen on its label.
Not entries in our interaction table, but our inulin file lists Lactobacillus among the probiotics it feeds, and our GOS file names lactobacilli among the bacteria that ferment it. In Digestion & microbiome the three are served together, before breakfast.
Our file records a possible dairy origin for this strain, so milk is listed as an allergen and lactose intolerance as a related intolerance. Read the label if either applies to you.
No pair with another ingredient or with a medicine is documented for L. acidophilus, and our pharmacokinetic file found nothing on liver enzymes, half-life or bioavailability. That is an open question, not a clean result.
443 of the 9,730 possible pairs in our library are documented, which is 4.55%, and none of them involves L. acidophilus. The rest are not "safe", they are simply unchecked, and we would rather write that down than let the number look like a badge.443 of the 9,730 possible pairs in our library are documented, which is 4.55%, and none of them involves L. acidophilus. The rest are not safe, they are simply unchecked.
SOURCES
Everything on this page, with its reference.
Reviewed by VION nutrition team · last reviewed 16 September 2026
140 INGREDIENTS · 64 IN USE TODAY
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What it is, what we are allowed to say about it, which formulas carry it, what it reacts with and where each of those statements comes from. No proprietary blends, no hidden amounts.