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Phosphatidylserine (PS)
A phospholipid that sits on the inner side of cell membranes. It is in three of our formulas, all of them served in the morning, and it carries no authorised EU health claim, because EFSA assessed the ones made for it and turned them down.
WHAT WE ARE ALLOWED TO SAY
No authorised claim. EFSA turned them down.
EFSA assessed claims for phosphatidylserine on cognition, mental stress, nerve function, muscle function and performance, and none of them made it onto the EU register. So there is no wording to quote here, and we are not going to write a sentence that sounds like one.EFSA assessed claims for phosphatidylserine on cognition, mental stress, nerve function, muscle function and performance. None of them made it onto the EU register.
Where phosphatidylserine sits in a formula, the claims on that formula come from the ingredients next to it: DHA, folate and vitamin B12 in Cognition & memory, vitamin B6, vitamin B12 and magnesium in Stress & nervous system, and magnesium for the headline claim in Chronic cortisol. It is there as a supporting ingredient, not as the source of any claim.
WHY SOY-DERIVED
One form on file. It comes with an allergen.
Phosphatidylserine is usually made from soy lecithin, and the form in our file is soy-derived, concentrated to at least 20% PS. No form carries an authorised claim, so the choice is not a claim argument. What it does change is the label: soy is one of the fourteen allergens that must be declared in the EU.
Phosphatidylserine concentrated to at least 20% from soy. It carries a declared soy allergen, and that goes on the label of every formula that uses it.
Avoids the soy allergen. Our file lists it as an option that still has to be checked against the supplier's technical sheet, so we are not claiming it yet.
No form of phosphatidylserine has an authorised claim. Whatever the source, what we are allowed to say about it does not change.
Until the supplier's technical sheet says otherwise, treat the phosphatidylserine in our formulas as soy-derived and read the allergen on the label. If you are allergic to soy, check before taking any of the three formulas below.Until the supplier's technical sheet says otherwise, treat it as soy-derived. If you are allergic to soy, check the label first.
WHERE IT APPEARS
Three of the twenty-nine carry phosphatidylserine.
All three are served in the morning, and the dose is not the same in each. The only dose in our record is a minimum effective dose of 400 mg a day, over six to twelve weeks (an older note gives 300 – 400 mg). It is a minimum, not a limit. At 100 mg the two CORE formulas serve a quarter of it, and we would rather tell you that than leave it out.
THE CEILING
No upper limit on file. That is not the same as no limit.
EFSA has not published a numerical upper intake level for phosphatidylserine, so there is no ceiling to draw here. The only dose in our record is a minimum effective dose of 400 mg a day, over six to twelve weeks (an older note gives 300 – 400 mg). It is a minimum, not a limit. All three formulas that carry it are served in the morning, so if more than one were in your plan, the amounts would add up in the same window.EFSA has not published a numerical upper intake level for phosphatidylserine. The only dose in our record is a minimum effective dose of 400 mg a day, over six to twelve weeks. It is a minimum, not a limit.
A minimum effective dose of 400 mg a day, over six to twelve weeks (an older note gives 300 – 400 mg). Chronic cortisol serves 400 mg; Cognition & memory and Stress & nervous system serve 100 mg each, a quarter of it.
EFSA has not published a numerical upper limit. That means the question is still open, not that any amount is fine.
Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet. Keep out of reach of young children.
WHAT IT REACTS WITH
No documented pairs yet. Two warnings.
Phosphatidylserine is one of the 140 ingredients in our library, so it has 139 possible partners. None of them is among the 443 pairs we have documented so far. What we do have are two warnings on its label.
The form in our file is soy-derived, and soy must be declared as an allergen under Regulation (EU) 1169/2011, Annex II, unless the technical sheet says otherwise.
If you take anticoagulant medication, speak to a healthcare professional before taking it. Our label warning notes a possible additive effect.
No pair with another ingredient or with a medicine is documented for phosphatidylserine. That is an open question, not a clean result.
443 of the 9,730 possible pairs in our library are documented, which is 4.55%, and none of them involves phosphatidylserine. The rest are not "safe", they are simply unchecked, and we would rather write that down than let the number look like a badge.443 of the 9,730 possible pairs in our library are documented, which is 4.55%, and none of them involves phosphatidylserine. The rest are not safe, they are simply unchecked.
SOURCES
Everything on this page, with its reference.
Reviewed by VION nutrition team · last reviewed 16 September 2026Read the introduction to Phosphatidylserine →
140 INGREDIENTS · 64 IN USE TODAY
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What it is, what we are allowed to say about it, which formulas carry it, what it reacts with and where each of those statements comes from. No proprietary blends, no hidden amounts.