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Resveratrol
A polyphenol from the grapevine, sold mostly as an extract of Polygonum cuspidatum or made synthetically. EFSA assessed its claims for the heart and for antioxidant protection and rejected them, and its approval as a novel food, up to 150 mg a day, is about safety, not about an effect. It is in two of our formulas at 100 mg each, very little of it reaches your blood intact, and it slows your platelets down, which is behind most of what follows on this page.
WHAT WE ARE ALLOWED TO SAY
Nothing. The claims were assessed and rejected.
Regulation (EU) 432/2012 lists no authorised health claim for resveratrol. This is not a claim waiting in a queue: EFSA assessed claims on cardiovascular function and antioxidant protection in 2010 and did not accept them. Its approval as a novel food in 2016 is a safety decision, not a claim, so there is nothing on the register for us to quote here, and we are not going to write something that sounds like one.Regulation (EU) 432/2012 lists no authorised health claim for resveratrol. EFSA assessed its cardiovascular and antioxidant claims and rejected them. Its novel food approval is about safety only.
Resveratrol has no authorised claim for your heart, for oxidation or for blood sugar, however often you read otherwise. What our file describes is a set of mechanisms: it acts on SIRT1, which our file links to the effects of calorie restriction, on AMPK, on the COX-1 and COX-2 enzymes and on the eNOS that widens blood vessels. A mechanism is not a claim, and it is not a promise.
WHY TRANS-RESVERATROL
One molecule. Very little of it arrives.
Resveratrol is a stilbene, one kind of polyphenol, so there is no salt to choose, only a purity to meet. Our regulatory record requires trans-resveratrol at 98% or more. The catch is absorption: your gut takes it up, but your gut and liver convert most of it straight away, so around 1% reaches your blood as resveratrol. Its metabolites may keep part of the activity.
The form our regulatory record requires. The novel food approval on file covers synthetic trans-resveratrol, up to 150 mg a day for adults. Our file allows it synthetic or standardised from Polygonum cuspidatum, and prefers it micronised or complexed, so that more of it is absorbed.
Resveratrol bound to a sugar. It counts as the same ingredient: grape extracts, polydatin, red wine supplements and Polygonum products all add to the same daily total, and our file flags them as ways it could double up.
Not stable in a liquid and sensitive to light, which matters for a device that doses liquids. It works best at a pH of 5 to 7, tastes neutral, and comes in a concentrated form that takes up less room in the dose.
No form of resveratrol carries an authorised claim, so the purity is not a claim argument and we do not use it as one. It fixes what is in each 100 mg. Our file is still a draft with a preliminary confidence rating, pending review by a clinician, and the regulatory check on our current batch is still pending.No form of resveratrol carries an authorised claim. Our file is a draft with a preliminary confidence rating, pending clinical review, and the check on our current batch is still pending.
WHERE IT APPEARS
Two of the twenty-nine carry resveratrol.
Both are ADAPT formulas, both carry 100 mg, both serve it at night with dinner. That is below the 150 mg a day, over 12 weeks, that our file lists as the lowest effective dose, and both doses are marked as reduced for safety. Our file also suggests taking it in the morning or at midday, with a fatty meal. We would rather say so than let the name do the work.
THE CEILING
150 mg a day on file. A novel food limit, not an EFSA one.
EFSA has not formally set a tolerable upper intake level for resveratrol, and there is no NRV. The limit on file comes from its approval as a novel food: in 2016 EFSA considered 150 mg a day safe, and the EU authorised synthetic trans-resveratrol up to that amount in supplements for adults. Our engine holds your total to 150 mg a day across every formula, and blocks any formula that would take you past it. Each of our two formulas carries 100 mg, so they are never served together.EFSA has not set an upper limit for resveratrol. The limit on file is its novel food one, 150 mg a day, across everything you take, so our two 100 mg formulas are never served together.
Oxidative cardiovascular and Systemic inflammation both carry 100 mg. The engine counts the total, not each formula, so your plan holds one or the other, never both. Our notes also flag grape extracts, polydatin, red wine supplements and Polygonum products as ways the total could double up.
Well tolerated up to 500 mg a day, according to our file. Above 1 g a day it can cause nausea, diarrhoea, bloating and stomach cramps, and some studies report a slight rise in bilirubin with very high doses taken for a long time.
Not in pregnancy or breastfeeding, where there is not enough data, and not for anyone under 18. Take care with liver disease: Systemic inflammation is ruled out if you have it. Both formulas are ruled out if you take a vitamin K antagonist such as warfarin, and Systemic inflammation if you take any anticoagulant. If you are on anticoagulants, stop it 7–10 days before planned surgery. Talk to your oncologist first if you have cancer or are in cancer treatment, and take care with a hormone-dependent cancer: in lab studies it acts as a weak plant oestrogen, a point that is still debated.
WHAT IT REACTS WITH
Documented pairs, not hunches.
Resveratrol is one of the 140 ingredients in our library, so it has 139 possible partners. We have documented 15 of them so far, out of the 443 pairs on file. Five are classed as synergies: coenzyme Q10, FOS, soy isoflavones, piperine, which raises how much resveratrol you absorb by around 230%, and curcumin, which also slows your platelets down and is flagged if you are on anticoagulants. St John's wort speeds up how your body clears resveratrol, so the two are not formulated together, and CBD blocks the same liver enzymes, so high doses of both never share a cartridge. Resveratrol is also one of eight ingredients our engine counts as antiplatelet: two or more in one plan are flagged for bleeding risk, and blocked if you take an anticoagulant.
All four slow your platelets down as well, so the risk adds up. Ginkgo and black garlic are hard flags if you take an anticoagulant, and ginkgo is avoided next to it if you bleed easily. Black garlic comes off 7–10 days before surgery. Bromelain and papain are flagged for bleeding, bromelain at high doses.
Psyllium husk is kept one hour away, konjac glucomannan and white clay two hours, because they reduce how much you absorb. Activated charcoal binds polyphenols: never in the same dose, and at least three hours apart.
With anticoagulants such as warfarin, acenocoumarol, apixaban or dabigatran, it can change their effect and the bleeding risk adds up; the same goes for antiplatelets such as aspirin or clopidogrel, and for anti-inflammatory painkillers (NSAIDs). It slows the liver enzyme CYP3A4, which can raise the levels of statins, ciclosporin and other medicines broken down the same way, and to a lesser degree CYP2C9, CYP2D6 and CYP1A2. It may slightly add to diabetes medication, and the data with immunomodulators is mixed. Talk to your oncologist before combining it with cancer treatment. If you take any medication, ask a doctor first. The app asks about medication before this ingredient is ever assigned.
443 of the 9,730 possible pairs in our library are documented, which is 4.55%, and 15 of them involve resveratrol. The rest are not "safe", they are simply unchecked, and we would rather write that down than let the number look like a badge.443 of the 9,730 possible pairs in our library are documented, which is 4.55%, and 15 involve resveratrol. The rest are not safe, they are simply unchecked.
SOURCES
Everything on this page, with its reference.
Reviewed by VION nutrition team · last reviewed 16 September 2026Read the introduction to Resveratrol →
140 INGREDIENTS · 64 IN USE TODAY
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What it is, what we are allowed to say about it, which formulas carry it, what it reacts with and where each of those statements comes from. No proprietary blends, no hidden amounts.