NEVER TOGETHER
Sleep & circadian rhythm
The CORE sleep formula also carries 1 mg of melatonin and 200 mg of magnesium. Two formulas on the same night would carry 2 mg of melatonin, above the limit on file, and 400 mg of magnesium, above the 250 mg upper limit for supplemental magnesium. So the engine never serves both on the same night. The same magnesium limit applies to any other formula in your plan that carries it.
SPLIT ACROSS WINDOWS
Pre-workout
That formula carries 150 mg of caffeine and is never taken after 4 pm. A stimulant and a sedative are never served within eight hours of each other, so on a late training day the engine keeps the two apart or leaves one out.
TALK TO A DOCTOR FIRST
Not for everyone
Not for pregnancy or breastfeeding, lupus or other autoimmune conditions, advanced kidney disease, myasthenia gravis (high doses of magnesium are contraindicated there), or anyone on anticoagulants such as warfarin. Not for children under 12; under 18, only on a doctor's prescription. Never with alcohol, benzodiazepines, sleeping pills, barbiturates, opioids or other sedatives, including sedating antipsychotics and first-generation antihistamines, and never with gabapentin, pregabalin or St John's wort. Ask a doctor first if you have milder kidney disease — below a GFR of 30, supplemental magnesium is not for you without medical supervision — liver disease, a heart rhythm problem such as AV block, epilepsy or diabetes, if you have or have had a hormone-dependent cancer or are having cancer treatment, or if you take antidiabetics, immunosuppressants, beta-blockers, blood pressure medication, fluvoxamine, ciprofloxacin, digoxin, anti-epileptic medicines or the contraceptive pill. Keep quinolone antibiotics such as ciprofloxacin 2 hours before or 4–6 hours after it, levothyroxine at least 4 hours apart, and bisphosphonates and tetracyclines at least 2 hours apart. Have your magnesium checked if you have taken a proton pump inhibitor for more than three months. It causes drowsiness: do not drive or use machinery for 4–5 hours after it. Stop it at least two weeks before surgery, and see a doctor if you need it for more than four weeks or nothing has improved after two. The app asks before it ever suggests this one.