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Acute immunity
BOOST IMMUNITYPENDING CLINICAL VALIDATION

Acute immunity

Five ingredients for the first days of a cold, split between morning and night and taken for 10 days at most. Three of them carry an authorised EU claim for the normal function of the immune system. The two botanicals do not. It does not treat a cold, and this page says what each ingredient can and cannot be said to do.

WHENMorning & night, split in two
WITH FOODYes, ideally. Vitamin D3 needs some fat
DOSE VOLUME4.2 ml a day, in twenty-one 0.2 ml pulses
INGREDIENTS5 active, 0 fillers
CARTRIDGE45 ml · up to 10 days
SLOT1 of the 6 in your device

WHAT IS IN IT

Five actives. Nothing else.

These are the reference doses of the formula for a full day, at the full 4.2 ml across your morning and night windows. Your device pours in steps of 0.2 ml, so any pour below the full dose carries less of all five.

INGREDIENTFORMPER DOSE% NRVWHAT IT IS THERE FOR
Vitamin CL-ascorbic acid / magnesium ascorbate1,000 mg1250%Normal function of the immune system. Split between morning and night
ZincBisglycinate15 mg150%Normal function of the immune system
Vitamin D3Cholecalciferol25 µg500%Normal function of the immune system. The reason this formula goes with food
EchinaceaEchinacea purpurea2,400 mg—Short-term use in the common cold under an EMA monograph. Its EU claim is on hold, and it sets the 10-day limit
ElderberrySambucus nigra600 mg—Included on published work on cold symptoms, not on an authorised claim. Its EU claim is on hold
Total volume4.2 mlTwenty-one pulses of 0.2 ml a day, the smallest step the device can serve
Vitamin CL-ascorbic acid / magnesium ascorbate1,000 mg1250% NRV

Normal function of the immune system. Split between morning and night

ZincBisglycinate15 mg150% NRV

Normal function of the immune system

Vitamin D3Cholecalciferol25 µg500% NRV

Normal function of the immune system. The reason this formula goes with food

EchinaceaEchinacea purpurea2,400 mg—

Short-term use in the common cold under an EMA monograph. Its EU claim is on hold, and it sets the 10-day limit

ElderberrySambucus nigra600 mg—

Included on published work on cold symptoms, not on an authorised claim. Its EU claim is on hold

Total volume 4.2 ml 

Twenty-one pulses of 0.2 ml a day, the smallest step the device can serve

No proprietary blends, no "complex" hiding the amounts, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

No proprietary blends, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

THE SCIENCE BEHIND IT

Three of these five have an authorised claim. Two do not.

In the EU, only a short list of health claims is authorised, and botanical claims sit on hold. We would rather show you which of our ingredients are on that list and which are not than write a sentence that sounds the same for all five.

Vitamin C

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Vitamin C contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, which requires at least 15% of the NRV per dose. This formula carries 1,250%. A narrower claim, “Vitamin C contributes to the normal function of the immune system during and after intense physical exercise”, holds at 200 mg a day on top of your recommended intake. This formula carries more than that, but it is written for a cold, not for training, so we do not lean on it. EFSA has not set an upper limit for vitamin C; the US limit on file is 2,000 mg a day. Two national ceilings on file for supplements are lower: 1,000 mg in France, counting diet and supplements together, and 250 mg in Germany. The length of this course is set by the echinacea monograph, not by these figures.

Reg. 432/2012 · EFSA Journal 2009;7(9):1226 · 11 sources on file

Zinc

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Zinc contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, which requires at least 15% of the NRV per dose. This formula carries 150%. At 15 mg you are at 60% of the EFSA upper limit of 25 mg a day, so the engine keeps a running total of your zinc across formulas. Germany's recommended maximum for zinc in supplements is lower still, 6.5 mg a day, below this dose. Our own rule adds 1 mg of copper when zinc reaches 15 mg a day over the long term, because zinc crowds copper out. This formula carries no copper. It is a course of up to 10 days, not long-term use, and whether the rule should apply here is one of the open points for the clinical review this formula is still pending.

Reg. 432/2012 · NRV 10 mg · 14 sources on file

Vitamin D3

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Vitamin D contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, which requires at least 15% of the NRV per dose. The NRV for vitamin D is only 5 µg, so 25 µg reads as 500%. That is still a quarter of the EFSA upper limit of 100 µg a day. Germany's recommended maximum for vitamin D in supplements is lower, 20 µg a day, below this dose. It dissolves in fat, which is why this formula is best taken with food.

Reg. 432/2012 · EFSA Journal 2010;8(2):1468 · 12 sources on file

Echinacea

ON HOLD IN THE EU REGISTER

WHAT WE ARE ALLOWED TO SAY

Nothing yet. Botanical claims have been on hold in the EU since 2010, pending review.

Recognised by an EMA monograph for short-term use in the common cold, not by an authorised EFSA claim. The same monograph sets the length of this formula: “For prevention and treatment, do not use the medicinal product for more than 10 days.” The 2,400 mg here matches the daily amount on file for the pressed juice of the plant. Our file gives a lower range for dried extract, up to 1,200 mg a day, so the preparation that goes into the cartridge decides whether this dose fits. That is one of the open points for the clinical review this formula is still pending, and we would rather show it than hide it.

EMA/HMPC/48704/2014 · 5 sources on file · 1 with a PMID · claim on hold

Elderberry

ON HOLD IN THE EU REGISTER

WHAT WE ARE ALLOWED TO SAY

Nothing yet. Botanical claims have been on hold in the EU since 2010, pending review.

It is here because a meta-analysis on file, pooling four trials, reports shorter cold symptoms. That is a reason to include it, not a permission to promise anything. Two things we pass on as they are: our file records a minimum effective dose of 1,500 mg a day for elderberry, with a legacy range of 600–1,500 mg, so the 600 mg in this formula sits below that figure; and our notes record a 7-day limit for its traditional use in colds, shorter than this 10-day course. Both are open points for the clinical review this formula is still pending. It is only ever used as a processed extract: raw elderberries are toxic.

1 source on file · 1 with a PMID · claim on hold

HOW IT IS POURED

Twenty-one pulses. No marker moves them yet.

The full dose of this formula is 4.2 ml a day, which the device serves as twenty-one pulses of 0.2 ml across your morning and night windows. For some formulas, your band decides how many. For this one there is no marker in your data that should move the dose: it is judged by how your symptoms respond, which only you can tell. So the reference is the full twenty-one. A partial pour would carry less of all five, and the echinacea would fall below the pressed-juice amount on file.

TONIGHT'S POUR

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4.2 ml of 4.2 mlno marker moves this dose yet

MORNING & NIGHT

Why twice

The vitamin C is split, about 500 mg in the morning and 500 mg at night, because it does not stay in your blood for long and you absorb less of it in one large dose. The zinc sits fine in either window.

WITH FOOD, PREFERABLY

Why with food

Vitamin D3 dissolves in fat, and you absorb it better with a meal that has some fat in it. A high dose of vitamin C also sits easier on your stomach with food. Zinc would absorb a little better away from food and dairy, but a light meal helps if it makes you queasy. The D3 decides it: food wins.

45 ML CARTRIDGE

How long it lasts

At the full 4.2 ml a day it is 10 days, which is also the longest this formula should run in a row. The cartridge and the course end together. At a partial pour it lasts longer, so the app tracks what you actually took.

HOW IT ENTERS YOUR PLAN

A BOOST formula is not assigned. It is suggested.

BOOST is the part of your plan that moves. Most BOOST formulas are brought in by your wearable. This one moves with a cold instead: it starts at the first signs of one, runs as a short course and stops. For everyday use, the base formula is Immunity, not this one.

  1. 01

    It starts at the first signs of a cold

    That is the rule on file. No signal in your wearable data is tied to this formula yet, so your band does not bring it in. Picking immunity as one of your goals in the questionnaire makes it more likely to be offered.

  2. 02

    Your profile is checked first

    Before it is ever offered, your answers are checked against its exclusions. If you have an autoimmune condition, are immunosuppressed or take a vitamin K antagonist anticoagulant such as warfarin or acenocoumarol, it is not suggested at all.

  3. 03

    It runs for 10 days at most

    The EMA monograph for echinacea says: “For prevention and treatment, do not use the medicinal product for more than 10 days.” That is a ceiling, not a target. Inside it, the recipe does not change.

  4. 04

    If it lasts past 10 days, see a doctor

    The same monograph says: “If the symptoms persist for more than 10 days, a doctor or a pharmacist should be consulted.” We pass that on as it is. The course can be run again for a later cold: no official document on file fixes a washout between courses, and no yearly limit is documented. Our echinacea file does set a ceiling on the total, though — no more than 8 weeks of echinacea in all, and a break of at least 2 weeks after that.

SAFETY AND INTERACTIONS

What it is checked against.

Every pair of ingredients in our library is checked against the others before a plan is built. Inside this formula, two of the ten possible pairs are documented, both as complementary: vitamin C with zinc, and vitamin D3 with zinc. The other eight are not documented yet. One of them matters: our echinacea file warns against pairing it with another immune-stimulating botanical such as elderberry in the same dose, and this formula does exactly that. It is an open point for the clinical review this formula is still pending. Outside this formula, two more documented pairs matter: vitamin B12 is kept 2 hours away from a dose of vitamin C this size, and high-dose caffeine is not co-formulated with echinacea. Acute energy, linked below, carries caffeine, vitamin B12 and 500 mg of vitamin C, which would also take your two-formula vitamin C total to 1,500 mg, above the 1,000 mg our vitamin C file allows across two formulas.

NEVER TOGETHER

Cold symptom support

The other cold formula carries the same 1,000 mg of vitamin C, 15 mg of zinc, 25 µg of vitamin D3 and 600 mg of elderberry. Together your zinc would reach 30 mg, above the EFSA upper limit of 25 mg, so the engine never runs both at once.

NEVER TOGETHER

Immunity

The CORE formula carries 10 mg of zinc, 25 µg of vitamin D3, 200 mg of vitamin C and 600 mg of echinacea. Next to this one, your zinc would reach 25 mg, the EFSA upper limit, and rule R11 blocks any formula that takes a total to its limit, so the two never run at once. The same count runs on the vitamin D3 in any formula you are on. The echinacea would add up to 3,000 mg, while our echinacea file caps the daily sum at 1,200 mg of dried extract and asks for a single major immune stimulant at a time. Our vitamin C file also sets a combined ceiling of 1,000 mg a day across two formulas, and this one uses all of it on its own.

TALK TO A DOCTOR FIRST

Not for everyone

Not for you if you have an autoimmune condition (including lupus, rheumatoid arthritis, multiple sclerosis, scleroderma, inflammatory bowel disease, vitiligo or active psoriasis), severe atopy, an organ transplant, advanced HIV, active tuberculosis, leukaemia or lymphoma; if you are immunosuppressed or take immunosuppressants such as ciclosporin, tacrolimus, methotrexate or anti-TNF biologics; if you take vitamin K antagonist anticoagulants; if you are allergic to the daisy family (Asteraceae); if you have Menkes disease; if you are pregnant or breastfeeding; or for children under 12. Talk to a doctor first if you are under 18; take other anticoagulants or antiplatelets (warfarin, acenocoumarol, apixaban, dabigatran), digoxin, thiazide diuretics, corticosteroids, orlistat, statins, anticonvulsants such as phenytoin, phenobarbital or carbamazepine, deferoxamine, cisplatin or any other cancer treatment, ACE inhibitors, azole antifungals, antiretrovirals, the contraceptive pill, antacids (aluminium antacids in particular), medicines broken down by the liver such as midazolam, theophylline or caffeine in high doses, or medicines that strain the liver such as paracetamol, isoniazid, methotrexate or anabolic steroids; have calcium kidney stones or a history of oxalate stones, liver disease, high blood calcium, sarcoidosis or primary hyperparathyroidism, haemochromatosis, thalassaemia or other iron overload, G6PD deficiency or histamine intolerance; have lost your sense of smell or use intranasal zinc products; or already take zinc, vitamin C or vitamin D from other supplements. Keep quinolone antibiotics 2 hours before or 4–6 hours after it, tetracyclines at least 2 hours apart, penicillamine at least 1 hour apart and bisphosphonates at least 30 minutes apart; keep iron of 25 mg or more, calcium of 500 mg or more and strong coffee or tea 2 hours away. Do not exceed 25 mg of zinc a day in total. If you have chronic kidney disease, this formula is above the limit our vitamin C file sets: it asks for no more than 500 mg a day in chronic kidney disease, because of the risk of calcium oxalate stones and hyperoxaluria, and this formula carries 1,000 mg. Echinacea can rarely cause allergic reactions, including anaphylaxis. Do not use it for more than 10 days in a row, and see a doctor or pharmacist if your symptoms last longer. Our echinacea file also caps total echinacea use at 8 weeks, with a break of at least 2 weeks after that. The elderberry is a processed extract; never eat raw elderberries, which are toxic. The vitamin D3 is not vegan. The app asks before it ever suggests this one.

WHERE THIS COMES FROM

Regulation (EU) 432/2012 on permitted health claims · EFSA Journal 2009;7(9):1226 on vitamin C and the immune system · EMA/HMPC monograph on Echinacea purpurea (EMA/HMPC/48704/2014) · EFSA tolerable upper intake levels for zinc and vitamin D · Regulation (EU) 1169/2011 on nutrient reference values. Every line on this page is tied to one of the 810 sources on file, and 443 of the 9,730 possible ingredient pairs in our library are documented so far.

WHERE IT COMES FROM

You can check every line of this page.

Five sources hold up this formula: the regulation that lets us make the claims, the EFSA opinion behind the vitamin C claims, the EMA monograph that sets the 10-day limit, the upper limits we stay under, and the reference values behind every NRV percentage.

REGULATIONRegulation (EU) 432/2012 — list of permitted health claims made on foodsimmune claims for vitamin C, vitamin D and zinc
EFSAEFSA Journal 2009;7(9):1226 — opinion on vitamin C, protection of cells from oxidative stress, normal collagen formation and the immune systembehind the vitamin C claims and the 200 mg condition
EMAEMA/HMPC/48704/2014 — European Union herbal monograph on Echinacea purpurea (L.) Moench, herba recens10-day limit, claim on hold
EFSA ULTolerable upper intake levels — zinc 25 mg and vitamin D 100 µg per day; none set for vitamin Cwe serve 15 mg and 25 µg
NRVRegulation (EU) 1169/2011, Annex XIII — nutrient reference valuesbehind every NRV percentage on this page

Reviewed by VION nutrition team · last reviewed 16 September 2026

WHAT IS NOT PROVEN YET

This formula has not completed clinical validation. Three of its five ingredients rest on an authorised EU claim, and the two botanicals rest on an EMA monograph and on a single meta-analysis on file. The combination itself has not been tested by us in a trial, and three questions are still open for the clinical review this formula is pending: the echinacea dose and preparation, the elderberry dose and course length, and whether the two botanicals belong in the same dose. When any of that changes, the result goes on this page, whatever it says.

YOU DO NOT PICK YOUR FORMULAS

Your data does.

The questionnaire and your first weeks of data decide which six of the 29 end up in your device. This page exists so you can read what one of them is before that happens.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition. Nothing here replaces a healthcare professional.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition.