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Immunity
CORE IMMUNITYPENDING CLINICAL VALIDATION

Immunity

Four vitamins and minerals with an authorised EU claim for the normal function of the immune system, and one botanical without one, taken with breakfast. It is a base formula held for weeks, not something to reach for when a cold starts. One of its five ingredients is still being reconsidered, and this page says why.

WHENMorning, with breakfast
WITH FOODYes, ideally. Vitamin D3 needs some fat
DOSE VOLUME1.0 ml, in five 0.2 ml pulses
INGREDIENTS5 active, 0 fillers
CARTRIDGE45 ml · up to 45 mornings
SLOT1 of the 6 in your device

WHAT IS IN IT

Five actives. Nothing else.

These are the reference doses of the formula, at the full 1.0 ml. Your device pours in steps of 0.2 ml, so any pour below the full dose carries less of all five.

INGREDIENTFORMPER DOSE% NRVWHAT IT IS THERE FOR
Vitamin C—200 mg250%Normal function of the immune system
Vitamin D3Cholecalciferol25 µg500%Normal function of the immune system. The reason this formula goes with breakfast
ZincBisglycinate10 mg100%Normal function of the immune system
SeleniumSelenomethionine55 µg100%Normal function of the immune system
EchinaceaEchinacea purpurea600 mg—Short-term use in the common cold under an EMA monograph. Its EU claim is on hold, and it is pending reformulation here
Total volume1.0 mlFive pulses of 0.2 ml, the smallest step the device can serve
Vitamin C—200 mg250% NRV

Normal function of the immune system

Vitamin D3Cholecalciferol25 µg500% NRV

Normal function of the immune system. The reason this formula goes with breakfast

ZincBisglycinate10 mg100% NRV

Normal function of the immune system

SeleniumSelenomethionine55 µg100% NRV

Normal function of the immune system

EchinaceaEchinacea purpurea600 mg—

Short-term use in the common cold under an EMA monograph. Its EU claim is on hold, and it is pending reformulation here

Total volume 1.0 ml 

Five pulses of 0.2 ml, the smallest step the device can serve

No proprietary blends, no "complex" hiding the amounts, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

No proprietary blends, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

THE SCIENCE BEHIND IT

Four of these five have an authorised claim. One does not.

In the EU, only a short list of health claims is authorised, and botanical claims sit on hold. We would rather show you which of our ingredients are on that list and which are not than write a sentence that sounds the same for all five.

Vitamin C

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Vitamin C contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, which requires at least 15% of the NRV per dose. This formula carries 250%. A narrower claim, “Vitamin C contributes to the normal function of the immune system during and after intense physical exercise”, only holds at 200 mg a day on top of your recommended intake of vitamin C. The full dose here is exactly 200 mg. A partial pour is not, so we do not lean on it.

Reg. 432/2012 · EFSA Journal 2009;7(9):1226 · 11 sources on file

Vitamin D3

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Vitamin D contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, which requires at least 15% of the NRV per dose. The NRV for vitamin D is only 5 µg, so 25 µg reads as 500%. That is still a quarter of the EFSA upper limit of 100 µg a day. It dissolves in fat, which is why this formula goes out with breakfast.

Reg. 432/2012 · EFSA Journal 2010;8(2):1468 · 12 sources on file

Zinc

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Zinc contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, which requires at least 15% of the NRV per dose. This formula carries 100%. At 10 mg you are at 40% of the EFSA upper limit of 25 mg a day, the closest of the four to its ceiling, so the engine keeps a running total of your zinc across formulas.

Reg. 432/2012 · NRV 10 mg · 14 sources on file

Selenium

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Selenium contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, which requires at least 15% of the NRV per dose. This formula carries 100%, which is 55 µg. Selenium has a narrow margin: the EFSA upper limit is 255 µg a day, and we hold ourselves to 200 µg a day across all your formulas.

Reg. 432/2012 · NRV 55 µg · 15 sources on file

Echinacea

ON HOLD IN THE EU REGISTER

WHAT WE ARE ALLOWED TO SAY

Nothing yet. Botanical claims have been on hold in the EU since 2010, pending review.

Recognised by an EMA monograph for short-term use in the common cold, not by an authorised EFSA claim. That same monograph is why this formula is pending reformulation: it says “For prevention and treatment, do not use the medicinal product for more than 10 days.” A base formula runs for weeks. We would rather show you the conflict than hide it.

EMA/HMPC monograph · 5 sources on file · 1 with a PMID · claim on hold

HOW IT IS POURED

Five pulses. No marker moves them yet.

The full dose of this formula is 1.0 ml, which the device serves as five pulses of 0.2 ml. For some formulas, your band decides how many. For this one we looked for a single marker in your data that should move the dose, and did not find one we could stand behind. So the reference is the full five. If it ever pours four, vitamin C drops to 160 mg, below the 200 mg that one of its claims needs. The general immune claims hold either way.

TONIGHT'S POUR

12345
1.0 ml of 1.0 mlno single marker moves this dose yet

MORNING, WITH BREAKFAST

Why then

Vitamin D3 dissolves in fat, and you absorb it better with a meal that has some fat in it. Breakfast is the meal this formula rides on, which is why it sits in your morning slot.

WITH FOOD, PREFERABLY

Why with food

Vitamin C and selenium sit easier on your stomach with food. Zinc absorbs better on an empty stomach and away from dairy: a breakfast built on wholegrains or pulses can cut its absorption by about half, and 500 mg or more of calcium, 25 mg or more of iron, or strong coffee or tea in the same moment, cut it too — those want 2 hours' distance. The D3 decides it: food wins.

45 ML CARTRIDGE

How long it lasts

At the full 1.0 ml it is 45 mornings. At a partial pour it lasts longer, so the app orders your refill from what you actually took.

HOW IT ENTERS YOUR PLAN

A CORE formula is not suggested. It is assigned.

CORE is the part of your plan that stays still on purpose. It comes out of your questionnaire, not out of last night's data. This one carries an open question we would rather put here than in small print: the EMA limits echinacea to 10 days in a row, and a base formula runs for weeks. A clinician still has to decide how that is resolved.

  1. 01

    It comes from your questionnaire

    Your answers put this formula in your base. The same answers keep it away from you if you have an autoimmune condition or liver disease, are immunosuppressed, or take vitamin K antagonist anticoagulants such as warfarin or acenocoumarol.

  2. 02

    It is held for at least 21 days

    Long enough for a change to be a signal rather than noise. Nothing about this formula moves inside that window.

  3. 03

    It runs in cycles, with a break

    The current schedule is 12 weeks on and 2 weeks off, up to four cycles a year. That is VION's own clinical consensus, not a regulatory rule, and it is still waiting for review by a clinical professional. It is also not settled: four full cycles would run longer than a year, another entry in the same source says a CORE formula is continuous use and needs no pause at all, and a third gives 45 days as the recommended length. We would rather show you that than pick one.

  4. 04

    Your vitamin D is rechecked at three months

    A blood test for 25-OH vitamin D at three months is the check for whether the D3 dose should change. If your answers change at your next review, this cartridge comes out and its slot goes to whatever your base needs instead. You are told before it happens.

SAFETY AND INTERACTIONS

What it is checked against.

Every pair of ingredients in our library is checked against the others before a plan is built. Inside this formula, four of the ten possible pairs are documented, and none of them rules anything out at these doses, provided the selenium is selenomethionine, our preferred form. With selenite, a vitamin C booster above 500 mg would have to be kept 2 hours apart. Outside the formula, three things are worth knowing. Echinacea raises how much caffeine stays in your blood by about 30%, so our rule is not to combine it with high-dose caffeine. If Iron is also in your plan, it goes out in the same morning window, and its 28 mg is enough to cut the absorption of the zinc in here, so the two want 2 hours between them. And because of the vitamin D3 in here, the engine looks for vitamin K2 and magnesium elsewhere in your plan, and watches your calcium if you also take Bones & joints.

NOT STACKED AS IS

Acute immunity · Cold symptom support

Both BOOST formulas carry another 15 mg of zinc and another 25 µg of vitamin D3. Next to this one your zinc reaches 25 mg, which is the EFSA upper limit itself: the engine flags reaching it, not only passing it, and at 25 mg it also asks for 1 mg of copper alongside the zinc or blocks the combination. The sums do not stop there. Either BOOST takes your vitamin C to 1,200 mg a day, above the 1,000 mg we allow when an ingredient sits in two active formulas. Both add elderberry, a second major immune stimulant, and our rule is one at a time. And with Acute immunity your echinacea would reach 3,000 mg a day, against the 1,200 mg a day we allow summed. None of these stacks is served as it stands.

ABOVE OUR OWN CEILING

Autoimmune thyroid

That formula carries 200 µg of selenium. With the 55 µg here you would be at 255 µg, the EFSA upper limit, and above the 200 µg a day we set as our own ceiling for selenium across formulas. It is also written for an autoimmune condition, one of the profiles this formula is never assigned to.

TALK TO A DOCTOR FIRST

Not for everyone

Not for you if you have an autoimmune condition (including lupus, rheumatoid arthritis, multiple sclerosis, scleroderma, inflammatory bowel disease, vitiligo or active psoriasis), liver disease, an organ transplant, advanced HIV, active tuberculosis, leukaemia or lymphoma; if you are immunosuppressed or take immunosuppressants; if you take vitamin K antagonist anticoagulants such as warfarin or acenocoumarol; if you are allergic to the daisy family (Asteraceae); if you have had selenium toxicity, have high blood selenium or a known hypersensitivity to selenium; if you have Menkes disease; if you are pregnant or breastfeeding; or for children under 12. Talk to a doctor first if you are under 18; take other anticoagulants such as apixaban or dabigatran, or antiplatelets; take digoxin, thiazide diuretics, anticonvulsants, statins, systemic corticosteroids such as prednisone, orlistat, quinolone or tetracycline antibiotics, penicillamine, bisphosphonates, deferoxamine, aluminium-containing antacids, levothyroxine or antithyroid medicines, ciclosporin or other medicines broken down by the liver, azole antifungals, antiretrovirals, long-term medicines that strain the liver such as paracetamol or isoniazid, or any cancer treatment; have kidney disease or calcium kidney stones, high blood calcium, sarcoidosis or primary hyperparathyroidism, haemochromatosis, thalassaemia or other iron overload, G6PD deficiency, or type 2 diabetes with high selenium levels; have lost your sense of smell or use intranasal zinc products; or already take zinc, selenium or vitamin D from other supplements. Stop and ask if you notice yellowing skin or eyes, unusual tiredness, abdominal pain or dark urine. If you do take any of them, the zinc here needs at least 2 hours' separation from penicillamine, from tetracyclines and from bisphosphonates, and 2 hours before or 4 to 6 hours after a quinolone; the selenium needs at least 4 hours from levothyroxine. The EMA limits echinacea to 10 days in a row, and never more than 8 weeks in total. The vitamin D3 is not vegan. The app asks before it ever assigns this one.

WHERE THIS COMES FROM

Regulation (EU) 432/2012 on permitted health claims · EFSA Journal 2009;7(9):1226 on vitamin C and the immune system · EMA/HMPC monograph on Echinacea purpurea (EMA/HMPC/48704/2014) · EFSA tolerable upper intake levels for zinc, selenium and vitamin D · Regulation (EU) 1169/2011 on nutrient reference values. Every line on this page is tied to one of the 810 sources on file, and 443 of the 9,730 possible ingredient pairs in our library are documented so far.

WHERE IT COMES FROM

You can check every line of this page.

Five sources hold up this formula: the regulation that lets us make the claims, the EFSA opinion behind the vitamin C claims, the EMA monograph for the botanical and its 10-day limit, the upper limits we stay under, and the reference values behind every NRV percentage.

REGULATIONRegulation (EU) 432/2012 — list of permitted health claims made on foodsimmune claims for vitamin C, vitamin D, zinc and selenium
EFSAEFSA Journal 2009;7(9):1226 — opinion on vitamin C, protection of cells from oxidative stress, normal collagen formation and the immune systembehind the vitamin C claims and the 200 mg condition
EMAEMA/HMPC/48704/2014 — European Union herbal monograph on Echinacea purpurea (L.) Moench, herba recens10-day limit, claim on hold
EFSA ULTolerable upper intake levels — zinc 25 mg, selenium 255 µg and vitamin D 100 µg per daywe serve 10 mg, 55 µg and 25 µg — under EFSA, above Germany's stricter BfR maximums for supplements (6.5 mg, 45 µg and 20 µg)
NRVRegulation (EU) 1169/2011, Annex XIII — nutrient reference valuesbehind every NRV percentage on this page

Reviewed by VION nutrition team · last reviewed 16 September 2026

WHAT IS NOT PROVEN YET

This formula has not completed clinical validation. Four of its five ingredients rest on an authorised EU claim, but the combination itself has not been tested by us in a trial, and the echinacea in it is pending reformulation because its EMA limit of 10 days in a row does not fit a base formula. When either of those changes, the result goes on this page, whatever it says.

YOU DO NOT PICK YOUR FORMULAS

Your data does.

The questionnaire and your first weeks of data decide which six of the 29 end up in your device. This page exists so you can read what one of them is before that happens.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition. Nothing here replaces a healthcare professional.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition.