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Sleep & circadian rhythm
CORE SLEEP & RELAXATIONPENDING CLINICAL VALIDATION

Sleep & circadian rhythm

Four actives, taken at night about 30 minutes before sleep and away from food. Only one of them carries an authorised EU claim about sleep: at 1 mg taken shortly before going to bed, “Melatonin helps to reduce the time taken to fall asleep.” The other three are here for different reasons, and this page says what each one has behind it and what it does not.

WHENNight, 30–60 min before sleep
WITH FOODNo. Away from your meal
DOSE VOLUME2.0 ml, in ten 0.2 ml pulses
INGREDIENTS4 active
CARTRIDGE45 ml · up to 22 nights
SLOT1 of the 6 in your device
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WHAT IS IN IT

Four actives, at their reference doses.

These are the reference doses of the formula. Your device pours them in steps of 0.2 ml, so what you actually take on a given night can sit below the reference when your data does not call for the full dose.

INGREDIENTFORMPER DOSE% NRVWHAT IT IS THERE FOR
Melatonin—1 mg—Authorised EU claim at 1 mg, quoted below
MagnesiumBisglycinate200 mg53%Two authorised EU claims, quoted below
L-theanine—200 mg—No authorised claim. Included on published work, not on a claim
PassionflowerDry extract (3–5% flavonoids)500 mg—Traditional use for relief of mild symptoms of mental stress and to aid sleep (EMA/HMPC). No authorised EU claim
Total volume2.0 mlTen pulses of 0.2 ml, the smallest step the device can serve
Melatonin—1 mg—

Authorised EU claim at 1 mg, quoted below

MagnesiumBisglycinate200 mg53% NRV

Two authorised EU claims, quoted below

L-theanine—200 mg—

No authorised claim. Included on published work, not on a claim

PassionflowerDry extract (3–5% flavonoids)500 mg—

Traditional use for relief of mild symptoms of mental stress and to aid sleep (EMA/HMPC). No authorised EU claim

Total volume 2.0 ml 

Ten pulses of 0.2 ml, the smallest step the device can serve

No proprietary blends, no "complex" hiding the amounts, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

No proprietary blends, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

THE SCIENCE BEHIND IT

Two of these four have an authorised claim. Two do not.

In the EU, only a short list of health claims is authorised, and the rest of the register sits on hold. We would rather show you which of our ingredients are on that list and which are not than write a sentence that sounds the same for all four.

Melatonin

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Melatonin helps to reduce the time taken to fall asleep.”

Regulation (EU) 1170/2011, on one condition: 1 mg of melatonin taken shortly before going to bed. The claim is also listed in Regulation (EU) 432/2012, again at 1 mg per serving. This formula carries exactly 1 mg at its full dose. On a night the device pours less than the full dose, you get less than 1 mg, and the claim does not cover that night.

Reg. 1170/2011 · Reg. 432/2012 · EFSA Journal 2011;9(6):2241 · 10 sources on file

Magnesium

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Magnesium contributes to normal functioning of the nervous system.” “Magnesium contributes to normal psychological function.”

Regulation (EU) 432/2012, which only allows these claims on a product that is at least a source of magnesium under Regulation (EC) 1924/2006. This formula carries 200 mg, 53% of the NRV. The bisglycinate form is used because it is gentle on the gut, not for a stronger claim.

Reg. 432/2012 · EFSA Journal 2009;7(9):1216 and 2010;8(10):1807 · NRV 375 mg · 14 sources on file

L-theanine

NO AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

Nothing. EFSA rejected the claims submitted for it, so we do not attribute an effect to it.

It has no authorised EU claim. It is included on published work, and our library records it as combinable with the magnesium and the melatonin in the same pour. That is a reason to include it, not a permission to promise anything.

EFSA Journal 2011;9(6):2238 · 8 sources on file · 2 with a PMID · not a claim

Passionflower

ON HOLD IN THE EU REGISTER

WHAT WE ARE ALLOWED TO SAY

Nothing. It has no authorised claim, and botanical claims remain on the EU on-hold list.

The EMA/HMPC monograph recognises it as traditional use only, for relief of mild symptoms of mental stress and to aid sleep. It also says that if symptoms persist longer than 2 weeks, a doctor should be consulted, and this formula follows that rule. If the register ever resolves botanical claims, we will update this page and say what changed.

EMA/HMPC/669740/2013 · 6 sources on file · claim on hold

HOW IT IS POURED

Ten pulses. Not always ten.

The full dose of this formula is 2.0 ml, which the device serves as ten pulses of 0.2 ml. On a night when your sleep data says you do not need the whole thing, it pours seven and tells you why. On those nights you take less than 1 mg of melatonin, and the authorised claim, which is set at 1 mg, does not apply to them. A pressed pill has one setting. This has ten.

TONIGHT'S POUR

12345678910
1.4 ml of 2.0 mlyour total and deep sleep were back in your band

NIGHT, 30–60 MIN BEFORE SLEEP

Why then

The melatonin claim only holds when it is taken close to bedtime. Earlier than that and the dose stops matching the evidence it rests on. It is never served in the morning: the reason on file is that these four actives are sedative and work against a stimulant in the same window.

AWAY FROM YOUR MEAL

Why not with dinner

Fat in a meal delays how fast melatonin is absorbed, by about three hours on the figures on file. On an empty stomach it arrives when it is meant to. The magnesium here is bisglycinate, which is tolerated without food.

45 ML CARTRIDGE

How long it lasts

At the full 2.0 ml it is 22 nights. At a partial pour it lasts longer, so the app orders your refill from what you actually took.

HOW IT ENTERS YOUR PLAN

A CORE formula is not suggested. It is assigned.

CORE is the part of your plan that stays still on purpose. It comes out of your questionnaire, not out of last night's sleep. For this formula it runs as a course of up to 28 days, with a review at two weeks.

  1. 01

    It comes from your questionnaire

    Your answers put this formula in your base, and they are checked against its exclusions first. No wearable data is needed for that first decision.

  2. 02

    It runs as a course of up to 28 days

    That is the frame on file for continued use, set by the passionflower monograph. The recipe does not change inside it. A course can be repeated; no fixed break between courses is documented.

  3. 03

    At two weeks, it is reviewed

    If trouble sleeping or tension is still there after two weeks, the advice on file is to see a doctor to rule out an underlying cause, and we pass it on. It only continues towards 28 days if it is helping.

  4. 04

    Only the amount moves, night by night

    Inside the course, the engine adjusts how much of the 2.0 ml you get, in 0.2 ml steps, from your total sleep and your deep and REM sleep over the last few days.

SAFETY AND INTERACTIONS

What it never shares a day with.

Before a plan is built, the ingredient pairs documented in our library are checked, along with the daily limits on file. So far 443 of the 9,730 possible ingredient pairs are documented. This is what that check means for this formula.

NEVER ON THE SAME DAY

Relax & fast sleep

The BOOST sleep formula also carries 1 mg of melatonin and 200 mg of magnesium. Together that would be 2 mg of melatonin, over the 1 mg a day on file and the 1.9 mg a day allowed in Spain without a prescription, and 400 mg of magnesium, over the 250 mg a day limit for supplemental magnesium. This formula on its own already sits at that 1 mg melatonin ceiling. The engine's upper-limit rule blocks adding a formula that would pass the magnesium limit, so the two are not combined.

COUNTED TOGETHER

Every other magnesium formula

Nine other VION formulas carry 100 to 200 mg of magnesium, Bones & joints among them, also at night. Any of them on the same day as this one would pass the 250 mg a day limit for supplemental magnesium, so the engine will not add it. The limit is a daily total, so moving a dose to another window does not change it. Formulas with caffeine or other stimulants are kept at least 8 hours away from this one. With Cognitive & focus, which carries another 200 mg of L-theanine, your day would reach 400 mg: the ceiling the L-theanine file sets for combined use, and above the 250 mg a day upper level recorded for it in our regulatory table.

NOT FOR YOU IF

Or ask a doctor first

Not for you if you are pregnant or breastfeeding, have liver disease or an autoimmune condition such as lupus, rheumatoid arthritis or MS, or take a vitamin K antagonist such as warfarin, whose effect melatonin can raise (INR); the app checks for these before it ever assigns this one. Not for advanced kidney disease either. Never with alcohol, sleeping pills, benzodiazepines, opioids or other sedatives. It can make you drowsy: do not drive or use machinery for 4–5 hours after it. Ask a doctor first if you are under 18; have myasthenia gravis, a high-grade heart block or another heart condition, epilepsy, diabetes, low blood pressure or histamine intolerance; are having cancer treatment (ask your oncologist); or take other anticoagulants, antidiabetics, immunosuppressants, beta-blockers, blood pressure medication, psychiatric medication, MAO inhibitors, fluvoxamine, ciprofloxacin or the contraceptive pill. Keep bisphosphonates and tetracycline antibiotics at least 2 hours apart from it, and have your magnesium checked if you have taken a proton pump inhibitor for more than three months. Stop it 1–2 weeks before surgery under general anaesthesia. If trouble sleeping or tension lasts more than 2 weeks, see a doctor, and see one before taking melatonin for more than 4 weeks. Do not exceed the daily dose, keep out of reach of young children, and do not use it in place of a varied, balanced diet.

WHERE THIS COMES FROM

Regulations (EU) 432/2012 and 1170/2011 on permitted health claims · EFSA Journal 2011;9(6):2241 on melatonin and sleep onset · EMA/HMPC monograph on Passiflora incarnata (EMA/HMPC/669740/2013) · EFSA tolerable upper intake level for supplemental magnesium. Every line on this page is tied to one of the 810 sources on file, and 443 of the 9,730 possible ingredient pairs in our library are documented so far.

WHERE IT COMES FROM

You can check every line of this page.

Four sources hold up this formula: the regulations that let us make the claims, the EFSA opinion behind the melatonin dose, the EMA monograph for the botanical, and the upper limit we stay under.

REGULATIONRegulations (EU) 432/2012 and 1170/2011 — permitted health claims made on foodsclaims for melatonin and magnesium
EFSAEFSA Journal 2011;9(6):2241 — opinion on melatonin and reduction of sleep onset latencysets the 1 mg condition
EMAEMA/HMPC monograph — Passiflora incarnata L., herba (EMA/HMPC/669740/2013)traditional use, 2-week rule, no authorised claim
EFSA ULTolerable upper intake level for supplemental magnesium — 250 mg per daywe serve 200 mg

Reviewed by VION nutrition team · last reviewed 16 September 2026

WHAT IS NOT PROVEN YET

This formula has not completed clinical validation. Its four ingredients rest on published work and, in two cases, on an authorised EU claim, but the combination itself has not been tested by us in a trial. When it is, the result goes on this page, whatever it says.

Others in the same area

See all 29 formulas  →
Relax & fast sleepBOOSTSleep & relaxationRelax & fast sleepStress & nervous systemCOREStress & anxietyStress & nervous systemImmunityCOREImmunityImmunitySkin, hair & nailsCOREHealthy agingSkin, hair & nails

YOU DO NOT PICK YOUR FORMULAS

Your data does.

The questionnaire and your first weeks of data decide which six of the 29 end up in your device. This page exists so you can read what one of them is before that happens.

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Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition. Nothing here replaces a healthcare professional.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition.