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B12 + folate
ADAPT BLOODWORKPENDING CLINICAL VALIDATION

B12 + folate

Three B vitamins, taken with breakfast, for one number your blood test can measure: homocysteine. All three carry the same authorised EU claim, and this page shows you which one. It is not a base formula: it starts from a blood test, runs for 12 weeks and is then checked against another one.

WHENMorning, with breakfast
WITH FOODPreferably. With your breakfast
DOSE VOLUME0.2 ml, in one 0.2 ml pulse
INGREDIENTS3 active, 0 fillers
CARTRIDGE45 ml · up to 225 mornings
SLOT1 of the 6 in your device
See if it is in your plan Back to the library

WHAT IS IN IT

Three actives. Nothing else.

These are the reference doses of the formula. The whole dose fits in a single 0.2 ml pulse, the smallest step your device can serve, so on a morning it is due, this is exactly what you take.

INGREDIENTFORMPER DOSE% NRVWHAT IT IS THERE FOR
Vitamin B12Methylcobalamin500 µg20,000%Normal homocysteine metabolism and normal red blood cell formation
Folate5-MTHF (calcium L-methylfolate)800 µg400%Normal homocysteine metabolism. Never served here without B12
Vitamin B6Pyridoxal-5-phosphate (P5P)2 mg143%Normal homocysteine metabolism. The claim this formula is built around
Total volume0.2 mlOne pulse of 0.2 ml, the smallest step the device can serve
Vitamin B12Methylcobalamin500 µg20,000% NRV

Normal homocysteine metabolism and normal red blood cell formation

Folate5-MTHF (calcium L-methylfolate)800 µg400% NRV

Normal homocysteine metabolism. Never served here without B12

Vitamin B6Pyridoxal-5-phosphate (P5P)2 mg143% NRV

Normal homocysteine metabolism. The claim this formula is built around

Total volume 0.2 ml 

One pulse of 0.2 ml, the smallest step the device can serve

No proprietary blends, no "complex" hiding the amounts, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

No proprietary blends, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

THE SCIENCE BEHIND IT

All three have an authorised claim. They share one.

In the EU, only a short list of health claims is authorised. Each of these three vitamins is on it for several functions, and one of them is the same for all three: normal homocysteine metabolism. That is the claim we show you below, word for word, because it is the one this formula is built around.

Vitamin B12

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Vitamin B12 contributes to normal homocysteine metabolism.”

Regulation (EU) 432/2012, on condition that a dose is at least a source of vitamin B12 under Regulation (EC) 1924/2006. This formula carries 500 µg, as methylcobalamin, the active form. That is a dose for refilling low stores over 12 weeks, not one for every day of your life, and EFSA has not set an upper limit for B12.

Reg. 432/2012 · EFSA Journal 2010;8(10):4114 · NRV 2.5 µg · 8 sources on file

Folate

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Folate contributes to normal homocysteine metabolism.”

Regulation (EU) 432/2012, under the same condition. This formula carries 800 µg, 400% of the NRV, as 5-MTHF, a form your body does not have to convert first. It stays under the 1,000 µg upper limit, and our rules never serve folate without B12: on its own it can correct the anaemia of a B12 deficiency while nerve damage goes on unnoticed.

Reg. 432/2012 · EFSA Journal 2009;7(9):1213 · NRV 200 µg · 9 sources on file

Vitamin B6

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Vitamin B6 contributes to normal homocysteine metabolism.”

Regulation (EU) 432/2012, under the same condition. This formula carries 2 mg, 143% of the NRV, as P5P, the active form. B6 works on a different branch of the same homocysteine pathway than B12 and folate do. The upper limit is 12 mg a day, and your B6 is counted across every formula you take.

Reg. 432/2012 · EFSA Journal 2010;8(10):1759 · NRV 1.4 mg · 8 sources on file

HOW IT IS POURED

One pulse. Never a fraction of one.

The full dose of this formula is 0.2 ml, a single pulse, and that is the smallest amount the device can serve. Our rules never split a pulse, so there is no partial morning here: on a day it is due, you get all of it. What decides whether it stays in your plan is your next blood test, not last night's data.

TONIGHT'S POUR

1
0.2 ml of 0.2 mla single pulse is never split

MORNING, WITH BREAKFAST

Why then

B12 can be activating, so it is kept out of the evening, where it could get in the way of your sleep. Folate, B12 and B6 work in the same methylation cycle, so the three go out together, in your first window.

WITH FOOD, PREFERABLY

Why with breakfast

B6 is easier on the stomach with a meal, and our notes on B12 favour taking it with food too. Folate works either way, so it simply goes with the other two.

45 ML CARTRIDGE

How long it lasts

At 0.2 ml a morning it is 225 mornings, far longer than the 12-week course this formula is built for. The app orders your refill from what you actually took.

HOW IT ENTERS YOUR PLAN

An ADAPT formula is not guessed. It is read from your blood.

ADAPT is the part of your plan that answers a lab result. It starts from a number, runs for a set period and ends with another test, so you can see whether that number moved.

  1. 01

    It starts from a blood test

    A raised homocysteine, or a B12 below 200 pg/ml, is what points the engine to this formula. Your answers on health and current medication are checked before it goes in. No wearable data is part of that decision.

  2. 02

    It runs for 12 weeks

    That is the standard length of a B12 and folate repletion course, and the recipe does not move inside it. The target is a homocysteine below 12 µmol/L by the end.

  3. 03

    At 12 weeks, you test again

    You repeat homocysteine and serum B12. If they are back in range, this formula comes out and you move to a maintenance dose, at the reference intake, inside Cognition & memory or Energy & vitality. No break is needed in between.

  4. 04

    If nothing moves, the question changes

    If homocysteine is still above 15 µmol/L, more of this formula is not the answer. The next step is to look at how well you absorb B12, with a doctor. If a deficiency comes back later, the course can be repeated. No official source sets a yearly cap, and we do not invent one.

SAFETY AND INTERACTIONS

What it is never stacked with, or served close to.

Every pair of ingredients in our library is checked against the others before a plan is built. This is what that check requires and rules out for this formula.

NOT STACKED AT FULL DOSE

Cognition & memory

That formula carries 400 µg of folate. With the 800 µg here it would be 1,200 µg, above the 1,000 µg upper limit, and our rule keeps your daily folate at 1,000 µg or less. It is one of the formulas you move to once your blood test is back in range, not one you take alongside this. Your B6 is counted the same way, against 12 mg a day.

2 HOURS APART

Acute immunity & Cold symptom support

Both carry 1,000 mg of vitamin C, and above 500 mg a dose vitamin C may break down B12. The evidence is weak and mostly from the lab, but the rule is conservative: those formulas are served at least two hours away from this one.

TALK TO A DOCTOR FIRST

Not for everyone

Ask a doctor first if you have an unexplained macrocytic anaemia (a B12 deficiency has to be ruled out before you take folate), cancer or are in cancer treatment, an MTHFR variant with a raised risk of bowel cancer, epilepsy, peripheral neuropathy, polycythaemia vera, Leber's optic atrophy or a cobalt allergy, or if you are under 18, where the upper limits for folate and B6 are lower. The same if you take levodopa without carbidopa, isoniazid, cycloserine, anticonvulsants such as phenytoin, carbamazepine, valproate or phenobarbital, methotrexate, trimethoprim, sulfasalazine, pyrimethamine, cholestyramine, hydralazine, penicillamine, theophylline, chloramphenicol or colchicine, or have had repeated nitrous oxide anaesthesia. Oral contraceptives can lower your folate and B6. On metformin, a proton pump inhibitor or an H2 blocker long term, tell your doctor: all of them can lower your B12. Pregnancy and breastfeeding do not rule it out: it is one of the few formulas our rules keep in that case. The app asks before it ever assigns this one.

WHERE THIS COMES FROM

Regulation (EU) 432/2012 on permitted health claims · EFSA Journal 2009;7(9):1213 on folate · EFSA tolerable upper intake levels for folate and vitamin B6 · EFSA 2015 on vitamin B12, with no upper limit set · Wald et al. 2002 on homocysteine. Every line on this page is tied to one of the 810 sources on file, and 443 of the 9,730 possible ingredient pairs in our library are documented so far.

WHERE IT COMES FROM

You can check every line of this page.

Seven sources hold up this formula: the regulation that lets us make the three claims, the EFSA opinion behind the folate claim, the regulation that sets the reference values, a meta-analysis on B vitamins and homocysteine, and the three EFSA reviews that set, or decline to set, an upper limit.

REGULATIONRegulation (EU) 432/2012 — list of permitted health claims made on foodshomocysteine claims for vitamin B12, folate and vitamin B6
EFSAEFSA Journal 2009;7(9):1213 — scientific opinion on folate (DOI 10.2903/j.efsa.2009.1213)backs the folate homocysteine claim
NRVRegulation (EU) 1169/2011, Annex XIII Part A — nutrient reference valuesthe % NRV column
META-ANALYSISWald, Law & Morris 2002, BMJ — Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis (DOI 10.1136/bmj.325.7374.1202)cited for B vitamins and homocysteine, not for any heart claim
EFSA ULEFSA Journal 2023 — tolerable upper intake level for folate, 1,000 µg per daywe serve 800 µg
EFSA ULEFSA Journal 2023 — tolerable upper intake level for vitamin B6, 12 mg per daywe serve 2 mg
EFSA DRVEFSA Journal 2015 — Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)no upper limit set; we serve 500 µg

Reviewed by VION nutrition team · last reviewed 16 September 2026

WHAT IS NOT PROVEN YET

This formula has not completed clinical validation. Its three ingredients rest on published work and each on an authorised EU claim, but the combination itself has not been tested by us in a trial. When it is, the result goes on this page, whatever it says.

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YOU DO NOT PICK YOUR FORMULAS

Your data does.

The questionnaire and your first weeks of data decide which six of the 29 end up in your device. This page exists so you can read what one of them is before that happens.

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Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition. Nothing here replaces a healthcare professional.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition.