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Glucose & metabolism
ADAPT BLOODWORKIN DEVELOPMENT

Glucose & metabolism

Five ingredients for when a blood test puts your fasting glucose or HbA1c in the range our file specifies: chromium, alpha-lipoic acid, cinnamon, vitamin B1 and magnesium, taken before breakfast. It is still in development. It runs for 12 weeks and ends with a new test, not with a promise.

WHENMorning, before breakfast
WITH FOODNo. Before breakfast, on an empty stomach
DOSE VOLUME3.2 ml, in sixteen 0.2 ml pulses
INGREDIENTS5 active, 0 fillers
CARTRIDGE45 ml · up to 14 mornings
SLOT1 of the 6 in your device
See if it is in your plan Back to the library

WHAT IS IN IT

Five actives. Nothing else.

These are the reference doses of the formula, at the full 3.2 ml. Your device pours in steps of 0.2 ml, but the plan on file for this one is the full dose every morning for 12 weeks. The species of one ingredient is still being checked, and we say which below.

INGREDIENTFORMPER DOSE% NRVWHAT IT IS THERE FOR
ChromiumPicolinate200 µg500%Maintenance of normal blood glucose levels and normal macronutrient metabolism
Alpha-lipoic acidR-ALA or racemic200 mg—No authorised claim. EFSA rejected every one submitted for it
CinnamonSpecies being confirmed1,000 mg—No authorised claim. Included on its botanical profile, with the species still being checked
Vitamin B1 (thiamine)Benfotiamine100 mg—Normal energy-yielding metabolism and normal function of the nervous system
MagnesiumBisglycinate200 mg53%Normal energy-yielding metabolism, the claim this formula is filed under
Total volume3.2 mlSixteen pulses of 0.2 ml, the smallest step the device can serve
ChromiumPicolinate200 µg500% NRV

Maintenance of normal blood glucose levels and normal macronutrient metabolism

Alpha-lipoic acidR-ALA or racemic200 mg—

No authorised claim. EFSA rejected every one submitted for it

CinnamonSpecies being confirmed1,000 mg—

No authorised claim. Included on its botanical profile, with the species still being checked

Vitamin B1 (thiamine)Benfotiamine100 mg—

Normal energy-yielding metabolism and normal function of the nervous system

MagnesiumBisglycinate200 mg53% NRV

Normal energy-yielding metabolism, the claim this formula is filed under

Total volume 3.2 ml 

Sixteen pulses of 0.2 ml, the smallest step the device can serve

No proprietary blends, no "complex" hiding the amounts, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

No proprietary blends, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

THE SCIENCE BEHIND IT

Three of these five have an authorised claim. Two do not.

In the EU, only a short list of health claims is authorised. Chromium is on it for normal blood glucose, and vitamin B1 and magnesium for normal energy-yielding metabolism. Alpha-lipoic acid was turned down, and cinnamon, like most botanicals, has no authorised claim. None of the three claims says anything about prediabetes or about bringing a blood result back into range.

Chromium

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Chromium contributes to the maintenance of normal blood glucose levels.”

Regulation (EU) 432/2012, on a product that is at least a source of trivalent chromium, which means 15% of the NRV, or 6 µg. This formula carries 200 µg, 500% of the 40 µg NRV. EFSA has set no upper limit for chromium, for lack of data. The German BfR suggests no more than 60 µg in a supplement, and this formula is more than three times that: our file records the higher dose as a deliberate therapeutic choice, and our label warnings cap it at 250 µg a day. It is also the reason for the firmest rule here: not with type 1 diabetes, because chromium can strengthen the effect of insulin.

Reg. 432/2012 · EFSA Journal 2010;8(10):1732 · NRV 40 µg · 1 source on file

Alpha-lipoic acid

NO AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

Nothing. EFSA looked at every claim submitted for it, blood glucose and insulin sensitivity included, and rejected them all.

It is here on trial work, not on a claim. The trial on file, SYDNEY 2, gave 600 mg a day for five weeks to 181 people with diabetic polyneuropathy. This formula carries 200 mg, a third of that, which our own file calls a preventive dose, below the one tested. 200 mg is also exactly the upper reference in our file for a supplement. That is a reason to include it, not a permission to promise anything.

EFSA Journal 2010;8(10):1474 · 2 sources on file · 1 with a PMID · claim rejected

Cinnamon

NO AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

Nothing. No authorised claim, and we do not claim a health benefit for it.

The ingredient on file is Cinnamomum cassia, and cassia carries coumarin. EFSA sets a tolerable daily intake for coumarin of 0.1 mg per kg of body weight, about 6 mg for a 60 kg adult, which our file turns into roughly 1–2 g of cassia a day. This formula carries 1,000 mg. Our file prefers Ceylon cinnamon (Cinnamomum verum), which carries far less coumarin, and the species in this formula is flagged to be confirmed before it goes out. Until then, we would rather tell you than round it off.

EFSA Journal 2008;6(11):874 · coumarin TDI 0.1 mg/kg · 1 source on file · no authorised claim

Vitamin B1 (thiamine)

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Thiamine contributes to normal energy-yielding metabolism.”

Regulation (EU) 432/2012, on a product that is at least a source of thiamine. The form here is benfotiamine, the fat-soluble one, at 100 mg, the top of the 50–100 mg our file lists as its therapeutic range. The reference intake for thiamine itself is 1.1 mg. We have not yet documented the thiamine equivalent of benfotiamine, so we print no percentage and the claim's condition, at least a source of thiamine, is still to be confirmed on file. EFSA has set no upper limit for it.

Reg. 432/2012 · EFSA Journal 2009;7(9):1222 · no EFSA upper limit · 2 sources on file

Magnesium

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Magnesium contributes to normal energy-yielding metabolism.”

Regulation (EU) 432/2012, on a product that is at least a source of magnesium, which means 15% of the NRV per dose. 200 mg is 53%. It is the claim this formula is filed under. 200 mg also leaves only 50 mg of room under the 250 mg upper limit for supplemental magnesium, which is why this formula cannot share a day with any other VION formula that carries it.

Reg. 432/2012 · EFSA Journal 2009;7(9):1216 · NRV 375 mg · UL 250 mg · 14 sources on file

HOW IT IS POURED

Sixteen pulses. Set by your blood test, not by last night.

The full dose of this formula is 3.2 ml, which the device serves as sixteen pulses of 0.2 ml. For some formulas, your band decides how many. For this one, no wearable marker in our library moves the dose: the plan on file is the full dose every morning for 12 weeks, then a new test. Fewer than five pulses would also drop the magnesium below the 15% of the NRV its claim needs.

TONIGHT'S POUR

12345678910111213141516
3.2 ml of 3.2 mlset by your blood test, not your band

MORNING, BEFORE BREAKFAST

Why then

The reason on file is the rise in blood glucose that follows a meal, so the formula is timed to come before breakfast, not after it. Our magnesium file prefers the bisglycinate form at night. This formula takes it in the morning, with the rest.

ON AN EMPTY STOMACH

Why not with breakfast

The timing rule on file for this formula asks for the alpha-lipoic acid on an empty stomach. Other VION formulas ride on your meal on purpose. This one comes before it.

45 ML CARTRIDGE

How long it lasts

At 3.2 ml a morning it is 14 mornings. One 12-week cycle is 84, so the cycle takes six cartridges, and the app orders each refill from what you actually took.

HOW IT ENTERS YOUR PLAN

An ADAPT formula starts with a blood test. It ends with another.

ADAPT is the part of your plan that follows your bloodwork. It goes in when a result is out of range, runs for a fixed period at a fixed dose, and comes out when a new test says so.

  1. 01

    It starts with a blood result

    Our file writes it for a fasting glucose of 100–125 mg/dl or an HbA1c of 5.7–6.4%. Not from your questionnaire, not from your band. HbA1c is not part of the VION blood panel yet, which is one reason this formula is still in development.

  2. 02

    It runs for 12 weeks

    84 days at the full dose, then a new HbA1c and fasting glucose. Twelve weeks is the usual point to re-test HbA1c, because it reflects about three months of blood glucose. Nothing about this formula moves inside that window.

  3. 03

    The next test decides what follows

    At 12 weeks you repeat HbA1c and fasting glucose, and the result decides whether it continues. If your HbA1c comes back above 6.5%, the rule on file is a referral to an endocrinologist.

  4. 04

    No fixed pause, no yearly cap

    The cycle can be repeated, under monitoring. We looked for a required break or a yearly limit in the EFSA opinions, the NIH fact sheet and the Cochrane review we checked, and found none, so we do not invent one.

SAFETY AND INTERACTIONS

What it never shares a day with.

Every pair of ingredients in our library is checked against the others before a plan is built. Inside this formula, none of the ten pairs between its five ingredients is documented yet. This is what the check does rule out.

UPPER LIMIT TRACKED

Every other formula with magnesium

Nine other VION formulas carry magnesium, from 100 mg in D3 / K2 and Daily athletic to 200 mg in Sleep & circadian rhythm, Bones & joints and Stress & nervous system. With the 200 mg here, even the smallest takes you to 300 mg, past the 250 mg upper limit for supplemental magnesium. The engine adds up your magnesium across every formula and blocks any addition that would take it over.

NOTHING ELSE ADDS TO IT

Chromium · Alpha-lipoic acid · Cinnamon

These three are in no other VION formula, so nothing else in your plan adds to them. That matters, because two of them already sit at or above a reference: 200 µg of chromium is more than three times the 60 µg the German BfR suggests for a supplement, and 200 mg of alpha-lipoic acid is exactly the upper reference in our file. The vitamin B1 also appears in Energy & vitality, at 1.1 mg, and EFSA sets no upper limit for it.

TALK TO A DOCTOR FIRST

Not for everyone

Ruled out if you have type 1 diabetes (chromium can strengthen the effect of insulin), if you are pregnant, or if you have liver disease. Magnesium at higher doses is ruled out too in myasthenia gravis, because it can worsen muscle weakness, and in advanced kidney disease. If you have diabetes and take insulin or glucose-lowering tablets, talk to your doctor first: chromium, alpha-lipoic acid and cinnamon each carry a warning for low blood sugar on top of that treatment, and your glucose needs watching. Cassia cinnamon carries coumarin, which can harm the liver at high intakes. Talk to a doctor first too if you take levothyroxine (alpha-lipoic acid may interfere with thyroid hormones, so your TSH should be checked, and magnesium needs 4 hours apart); if you have kidney disease, heart block or a slow heart rate, or histamine intolerance; if you have cancer or are in cancer treatment; if you are under 18; or if you take bisphosphonates or tetracycline antibiotics (at least 2 hours apart), quinolone antibiotics (take them 2 hours before or 4–6 hours after this formula), acid reducers (PPIs) long term, diuretics, digoxin, aminoglycosides, amphotericin B or calcium channel blockers. Iron supplements of 25 mg or more are best taken at a different time of day. Cinnamon may also change how your liver handles some medicines, so tell your doctor about anything you take regularly. Do not exceed the daily dose, and for chromium never more than 250 µg a day in total. A food supplement is not a substitute for a varied and balanced diet. Keep out of the reach of young children. The app asks before it ever assigns this one.

WHERE THIS COMES FROM

Regulation (EU) 432/2012 on permitted health claims · Regulation (EU) 1169/2011 on nutrient reference values · EFSA opinions on chromium (2010, 2011 and 2014), on coumarin (2008) and on alpha-lipoic acid claims (2010) · EFSA tolerable upper intake level for supplemental magnesium · BfR maximum levels for minerals in food supplements. Every line on this page is tied to one of the 810 sources on file, and 443 of the 9,730 possible ingredient pairs in our library are documented so far.

WHERE IT COMES FROM

You can check every line of this page.

Nine groups of sources hold up this formula: the regulation that lets us make three of the claims, the reference values we measure against, the EFSA opinions behind the chromium claim and its safety, the coumarin limit behind the cinnamon question, the EFSA rejection of every alpha-lipoic acid claim, the magnesium upper limit we stay under, the German chromium reference we do not, and the trial behind the alpha-lipoic acid.

REGULATIONRegulation (EU) 432/2012 — list of permitted health claims made on foodsclaims for chromium, vitamin B1 and magnesium
NRVRegulation (EU) 1169/2011, Annex XIII Part A — nutrient reference valuesthe 500% and 53% above
EFSA CLAIMEFSA Journal 2010;8(10):1732 and 2011;9(6):2203 — the opinions behind the chromium claimsbehind the blood glucose claim
EFSA SAFETYEFSA Journal 2010 (10.2903/j.efsa.2010.1733) — safety of trivalent chromium picolinate and nicotinate · EFSA Journal 2014 (10.2903/j.efsa.2014.3845) — dietary reference values for chromiumno upper limit set, for lack of data
EFSA COUMARINEFSA Journal 2008;6(11):874 — coumarin in flavourings and other food ingredients with flavouring propertiestolerable daily intake 0.1 mg/kg a day
EFSA ALAEFSA Journal 2010;8(10):1474 — substantiation of health claims related to alpha-lipoic acidevery claim rejected
EFSA ULTolerable upper intake level for supplemental magnesium — 250 mg per daywe serve 200 mg
BfRBfR-Wissenschaft 03/2018 — Höchstmengenvorschläge für Vitamine und Mineralstoffe in Nahrungsergänzungsmittelnchromium 60 µg: this formula is above it
TRIALZiegler et al. Diabetes Care 2006 — oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy (SYDNEY 2)used 600 mg a day; this formula carries 200 mg

Reviewed by VION nutrition team · last reviewed 16 September 2026

WHAT IS NOT PROVEN YET

This formula is still in development and has not been through clinical validation. Three of its five ingredients carry authorised EU claims, but none of those claims is about bringing a blood result back into range, and the combination has not been tested by us in a trial. Two points are still open: the cinnamon species, which our file flags to be confirmed, and HbA1c, which is not yet in our blood panel. When they are settled, and when the formula is tested, the result goes on this page, whatever it says.

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YOU DO NOT PICK YOUR FORMULAS

Your data does.

The questionnaire and your first weeks of data decide which six of the 29 end up in your device. This page exists so you can read what one of them is before that happens.

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Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition. Nothing here replaces a healthcare professional.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition.