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Systemic inflammation
ADAPT BLOODWORKPENDING CLINICAL VALIDATION

Systemic inflammation

Six ingredients for when your blood test shows low-grade inflammation: a high-sensitivity CRP between 1 and 3 mg/L. It runs as a two-week course and ends with a new test, not as something you stay on. And none of its six ingredients has an authorised EU claim for inflammation: we would rather tell you that than let the name promise it.

WHENNight, with dinner
WITH FOODYes, preferably. With your dinner
DOSE VOLUME3.0 ml, in fifteen 0.2 ml pulses
INGREDIENTS6 active, 0 fillers
CARTRIDGE45 ml · up to 15 nights
SLOT1 of the 6 in your device
See if it is in your plan Back to the library

WHAT IS IN IT

Six actives. Nothing else.

These are the reference doses of the formula, at the full 3.0 ml. Your device pours in steps of 0.2 ml, but the plan behind this one is written for the full dose every night of the course.

INGREDIENTFORMPER DOSE% NRVWHAT IT IS THERE FOR
CurcuminTurmeric extract, ≥95% curcuminoids500 mg—No authorised claim. The EMA recognises turmeric for digestive complaints only, not for inflammation
PiperineBlack pepper extract, ≥95% piperine5 mg—No claim. It is here to raise how much of the curcumin and resveratrol you absorb
EPA + DHAMarine oil, TG or phospholipid2,000 mg—Normal function of the heart, from 250 mg a day. No claim covers inflammation
Vitamin C—500 mg625%Protection of cells from oxidative damage
Resveratroltrans-Resveratrol, ≥98%100 mg—No authorised claim. EFSA rejected the claims made for it. Its dose is set lower for safety
ZincBisglycinate10 mg100%Normal function of the immune system and protection of cells from oxidative damage
Total volume3.0 mlFifteen pulses of 0.2 ml, the smallest step the device can serve
CurcuminTurmeric extract, ≥95% curcuminoids500 mg—

No authorised claim. The EMA recognises turmeric for digestive complaints only, not for inflammation

PiperineBlack pepper extract, ≥95% piperine5 mg—

No claim. It is here to raise how much of the curcumin and resveratrol you absorb

EPA + DHAMarine oil, TG or phospholipid2,000 mg—

Normal function of the heart, from 250 mg a day. No claim covers inflammation

Vitamin C—500 mg625% NRV

Protection of cells from oxidative damage

Resveratroltrans-Resveratrol, ≥98%100 mg—

No authorised claim. EFSA rejected the claims made for it. Its dose is set lower for safety

ZincBisglycinate10 mg100% NRV

Normal function of the immune system and protection of cells from oxidative damage

Total volume 3.0 ml 

Fifteen pulses of 0.2 ml, the smallest step the device can serve

No proprietary blends, no "complex" hiding the amounts, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

No proprietary blends, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.

THE SCIENCE BEHIND IT

Three of these six have an authorised claim. None is about inflammation.

In the EU, only a short list of health claims is authorised, and the rest of the register sits on hold or has been rejected. The name of this formula says what it is built for, not what it is allowed to promise. We would rather show you which of our ingredients are on that list, and what the list actually says, than write a sentence that sounds the same for all six.

Curcumin

ON HOLD IN THE EU REGISTER

WHAT WE ARE ALLOWED TO SAY

Nothing yet. Botanical claims have been on hold in the EU since 2010, pending review.

The EMA monograph recognises turmeric for traditional use in digestive complaints, for up to two weeks. It does not cover inflammation, so the use in this formula sits outside it, and that same monograph is where the two-week course comes from. The curcumin is paired with piperine to raise absorption, and that is where the caution comes from: cases of liver injury have been reported with highly absorbable curcumin, and the French agency ANSES advises staying under 153 mg of curcumin a day. Our own file sets 200 mg a day for absorbable forms. The ceilings above that do not agree with each other: our database records 1,000 mg a day as the EU upper limit, while the reference file gives a provisional acceptable daily intake of 0 to 3 mg of curcumin per kg of body weight, which it works out as about 210 mg for a 70 kg adult. This formula carries 500 mg, above every one of those figures except the 1,000 mg. We would rather show you that gap than hide it, and it is part of what clinical validation has to settle.

EMA/HMPC/329755/2017 · upper limit on file 1,000 mg · ADI about 210 mg · 7 sources on file · 1 with a PMID · claim on hold

Piperine

NO AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

Nothing. It has no authorised claim, and it is not here for an effect of its own.

Piperine, from black pepper, slows the breakdown of curcumin in your gut and liver, which our library puts at around twenty times more curcumin reaching your blood. It does the same for resveratrol, at around 230%. Both pairs are documented as ones to keep. The same effect reaches many medicines: our file records it raising the levels of some and weakening others, including the contraceptive pill. At 5 mg it is past the 200 µg a day at which our engine recalculates the safe maximums of everything else in your plan. It has no EMA monograph and no EFSA upper limit; our file keeps it under 20 mg a day and not beyond 12 weeks without supervision.

Planta Medica 1998 (Shoba et al.) · 5 sources on file · 1 with a PMID · not a claim

EPA + DHA

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“EPA and DHA contribute to the normal function of the heart.”

Regulation (EU) 432/2012, for a daily intake of 250 mg. This formula carries 2,000 mg, in triglyceride or phospholipid form rather than ethyl ester. It is also the main claim the whole formula is filed under, and it is about your heart, not about inflammation; we do not stretch it. The dose is high enough that our clinical notes rule this formula out if you take an anticoagulant, because of the bleeding risk. Our reference file on omega-3 is still a short one, with deeper research pending. It comes from fish.

Reg. 432/2012 · 250 mg a day minimum · UL 5,000 mg · 2 sources on file · 2 with a PMID

Vitamin C

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Vitamin C contributes to the protection of cells from oxidative damage.”

Regulation (EU) 432/2012, on a product that is at least a source of vitamin C. 500 mg is 625% of the NRV. EFSA has not set an upper limit for vitamin C; the US limit on file is 2,000 mg a day. Two national ceilings on file are lower: 1,000 mg in France, counting diet and supplements together, and 250 mg for a supplement in Germany, which this formula passes. VION has its own cap for vitamin C across formulas: 1,000 mg a day if two of your formulas carry it, 500 mg if more than two do. Our file also advises against more than 500 mg a day if you have kidney disease; this formula carries exactly 500 mg. Inside this formula, it is documented with zinc as a pair that works together.

Reg. 432/2012 · EFSA Journal 2009;7(9):1226 · NRV 80 mg · 11 sources on file

Resveratrol

NO AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

Nothing. EFSA assessed the claims made for it and rejected them, so we make none.

It is authorised in the EU as a novel food, up to 150 mg a day for adults. That approval is about safety, not about any effect. The dose here is 100 mg, set lower for safety, which also puts it below the 150 mg our file lists as the lowest effective dose, and very little of what you swallow reaches your blood intact. It is here because our library documents it with curcumin as an anti-inflammatory pairing, valid only outside anticoagulation, and because piperine raises how much of it you absorb. That is a reason to include it, not a permission to promise anything.

EFSA Journal 2010;8(10):1489 · novel food, 150 mg a day · 9 sources on file · 1 with a PMID · claim rejected

Zinc

AUTHORISED CLAIM

WHAT WE ARE ALLOWED TO SAY

“Zinc contributes to the normal function of the immune system.”

Regulation (EU) 432/2012, on a product that is at least a source of zinc. 10 mg is 100% of the NRV, and zinc shares with vitamin C the authorised claim on protecting cells from oxidative damage. At 10 mg you are at 40% of the EFSA upper limit of 25 mg a day, so the engine keeps a running total of your zinc across formulas. It stays under the 15 mg a day at which our rules call for copper alongside it. The German reference for a supplement is 6.5 mg, which this formula passes.

Reg. 432/2012 · EFSA Journal 2009;7(9):1229 · NRV 10 mg · UL 25 mg · 14 sources on file

HOW IT IS POURED

Fifteen pulses. Set by your blood test, not by last night.

The full dose of this formula is 3.0 ml, which the device serves as fifteen pulses of 0.2 ml. For some formulas, your band decides how many. For this one, no wearable marker in our library moves the dose: the plan on file is the full dose every night for two weeks, then a new hs-CRP test. Nothing about the recipe or the amount moves inside those two weeks.

TONIGHT'S POUR

123456789101112131415
3.0 ml of 3.0 mlset by your blood test, not your band

NIGHT, WITH DINNER

Why then

Our clinical notes put this formula at night, alongside the repair work your body does while you sleep. Taking the curcumin with dinner cuts down the stomach discomfort it can cause, and both the curcumin and the resveratrol are better taken up with a meal that has some fat in it. Our resveratrol file notes that some people prefer it earlier in the day; here it goes out at night with the rest.

AWAY FROM IRON AND CALCIUM

Why not with iron or calcium

Curcumin binds iron and cuts how much of it you absorb, so our library keeps the two at least two hours apart, and our zinc file asks for the same gap from a dose of iron like the one in the Iron formula. That formula goes out in the morning and this one at night, so they never meet. The same zinc file asks for no dairy in the same dose and at least two hours from a calcium supplement of 500 mg or more, so keep both away from the dinner you take this with. One tension we have not resolved: the curcumin file asks for two hours between curcumin and minerals, and this formula serves curcumin and zinc in the same dose. No pair in our library documents that combination, so we are flagging it rather than explaining it away.

45 ML CARTRIDGE

How long it lasts

At the full 3.0 ml it is 15 nights, which covers one full 14-day course with a night to spare. A second course means a second cartridge, and a new test before it.

HOW IT ENTERS YOUR PLAN

An ADAPT formula starts with a blood test. It ends with another.

ADAPT is the part of your plan that follows your bloodwork. It goes in when a result is out of range, runs for a fixed period at a fixed dose, and comes out when a new test says so.

  1. 01

    It starts with a blood result

    It is added when your high-sensitivity CRP, a blood marker of inflammation, comes back between 1 and 3 mg/L, the range our clinical notes treat as low-grade inflammation. Not from your band. A questionnaire route to this formula does exist in our data, but it points at an answer the questionnaire does not offer, so today the blood result is what starts it. Above 3 mg/L with no clear cause, this formula is not the answer: the advice on file is to find out why, whether that is an autoimmune condition, an infection or an underlying tumour.

  2. 02

    Your profile is checked first

    Before it is ever assigned, your answers are checked against its exclusions. If you take an anticoagulant, including warfarin or acenocoumarol, or have liver disease, it is not assigned at all.

  3. 03

    It runs for two weeks

    14 days at the full dose. Two weeks is the limit the EMA monograph sets for turmeric, the ingredient that caps the course, even though that monograph covers digestion, not inflammation. The target in our clinical notes is an hs-CRP under 1 mg/L by the end of it. That is what the next test checks, not a result we can promise.

  4. 04

    The next test decides what follows

    Your hs-CRP is tested again at two weeks. If it has come down clearly, the course can be repeated every two to three months. If it has not, or you feel worse, the advice on file is to see a doctor and look for the cause. No official source sets a break between courses. Our own limit is four courses a year, eight weeks of turmeric at most, for the sake of your liver. That is VION's decision, not a rule.

SAFETY AND INTERACTIONS

What it never shares a night with.

Every pair of ingredients in our library is checked against the others before a plan is built. Inside this formula, four of its fifteen pairs are documented: curcumin with piperine, piperine with resveratrol and vitamin C with zinc as pairings to keep, and curcumin with resveratrol as one to keep only outside anticoagulation. The other eleven are not documented yet. This is what the check rules out.

BLEEDING RISK FLAGGED

Inside this formula · Cognitive & focus

Curcumin and resveratrol both slow your platelets down, and our rules flag any plan with two such ingredients for bleeding risk, and block it if you take an anticoagulant. This formula has both on its own. Cognitive & focus adds 120 mg of ginkgo, which our library only pairs with curcumin below 120 mg of ginkgo and 100 mg of curcumin, and advises against next to resveratrol if you bleed easily. The vitamin E in Liver (ALT / AST) counts towards the same flag.

UPPER LIMIT TRACKED

Oxidative cardiovascular · Muscle damage (CK)

Oxidative cardiovascular carries another 100 mg of resveratrol: together you would reach 200 mg, past the 150 mg a day our file allows across all formulas. Muscle damage (CK) and Anti-inflammatory & recovery repeat the same 500 mg of curcumin, 5 mg of piperine and 2,000 mg of EPA + DHA. Next to either, your curcumin reaches 1,000 mg, the upper limit our database records for it; with both, 1,500 mg, past that limit, and your EPA + DHA would reach 6,000 mg, past the 5,000 mg upper limit. Acute immunity or Cold symptom support would take your zinc to 25 mg, the EFSA upper limit, and our rule blocks any formula that takes a total to its limit. Each of those two also carries 1,000 mg of vitamin C, which with the 500 mg here makes 1,500 mg: VION's own cap is 1,000 mg of vitamin C across two formulas, and 500 mg across three or more.

TALK TO A DOCTOR FIRST

Not for everyone

Not for you if you take an anticoagulant, including warfarin, acenocoumarol, apixaban or dabigatran; if you have liver disease; if you have a blocked bile duct or gallstones that cause symptoms; if you are pregnant or breastfeeding; if you are under 18; if you have a stomach ulcer or reflux; if you are allergic to fish; if you take several medicines at once; or if you are having chemotherapy. Those last two are not a matter of caution: our engine blocks the piperine in this formula outright when you declare either. If your CRP is above 3 mg/L with no clear cause, see a doctor instead. Ask a doctor first if you take antiplatelets such as aspirin or clopidogrel, anti-inflammatory painkillers (NSAIDs), diabetes or blood pressure medication, statins, ciclosporin, tacrolimus or other immunosuppressants, digoxin, talinolol, phenytoin, carbamazepine, theophylline, propranolol, rifampicin, lithium, SSRIs or SNRIs, tamoxifen, amlodipine, antiretrovirals, the contraceptive pill or other oestrogens, proton pump inhibitors or antacids, aluminium antacids, deferoxamine, niacin with a statin, thiazide diuretics, ACE inhibitors, cisplatin, or anything that has to be kept apart from the zinc: quinolone antibiotics 2 hours before or 4 to 6 hours after it, tetracycline antibiotics at least 2 hours apart, penicillamine at least 1 hour, bisphosphonates at least 30 minutes. Piperine and resveratrol change how your body handles many medicines, so if you take any regular medication, bring the full list. Ask first too if you have cancer, including a hormone-dependent cancer, where the advice on file is to check with your oncologist; or if you have a bleeding disorder, kidney disease or kidney stones, haemochromatosis, thalassaemia or another iron overload, iron-deficiency anaemia, G6PD deficiency, histamine intolerance or Menkes disease, or if you have lost your sense of smell. Do not combine it with zinc nasal sprays or gels. Stop it at least two weeks before planned surgery. Stop it and see a doctor if you notice yellowing skin or eyes, unusual tiredness, abdominal pain or dark urine, and see one too if your symptoms last more than two weeks or get worse. It contains fish and is not suitable for vegans or vegetarians. Do not exceed the dose, do not use it in place of a varied and balanced diet, and keep it out of reach of young children. The app asks before it ever assigns this one.

WHERE THIS COMES FROM

Regulation (EU) 432/2012 on permitted health claims · EFSA Journal 2009;7(9):1226 on vitamin C · EMA/HMPC/329755/2017 monograph on Curcuma longa L., rhizoma · EFSA Journal 2010;8(10):1489 on resveratrol · the upper limits for curcumin, EPA + DHA, zinc and resveratrol, and VION's own cap on vitamin C across formulas. Every line on this page is tied to one of the 810 sources on file, and 443 of the 9,730 possible ingredient pairs in our library are documented so far.

WHERE IT COMES FROM

You can check every line of this page.

Eight sources hold up this formula: the regulation that lets us make the claims, the EFSA opinion behind the vitamin C claim, the EMA monograph that caps the course at two weeks, the EFSA opinion that rejected the resveratrol claims, the French alert on curcumin, the study behind the piperine, the reference values for the NRV column, and the upper limits we count against.

REGULATIONRegulation (EU) 432/2012 — list of permitted health claims made on foodsclaims for EPA + DHA, vitamin C and zinc
EFSAEFSA Journal 2009;7(9):1226 — opinion on vitamin C, protection of cells from oxidative stress, normal collagen formation and the immune systembehind the vitamin C claim
EMAEMA/HMPC/329755/2017 — European Union herbal monograph on Curcuma longa L., rhizoma (Revision 1), 2018digestive use only, two weeks at most
EFSAEFSA Journal 2010;8(10):1489 — scientific opinion on resveratrol (cardiovascular, antioxidant)why resveratrol has no claim
ANSESANSES (France) — opinion on the safety of curcumin in food supplementsliver alert, under 153 mg of curcumin a day
STUDYShoba G. et al., Planta Medica 1998 — Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteerswhy the piperine is there
NRVRegulation (EU) 1169/2011, Annex XIII Part A — nutrient reference valuesvitamin C: 80 mg · zinc: 10 mg
UPPER LIMITSCurcumin 1,000 mg on file, against a JECFA/EFSA acceptable daily intake of 0–3 mg/kg that works out at about 210 mg · EPA + DHA 5,000 mg · zinc 25 mg (EFSA) · resveratrol 150 mg, the EU novel food limit (EFSA Journal 2016, 10.2903/j.efsa.2016.4368) · vitamin C: VION's own cap of 1,000 mg across two formulaswe serve 500 mg, 2,000 mg, 10 mg, 100 mg and 500 mg

Reviewed by VION nutrition team · last reviewed 16 September 2026

WHAT IS NOT PROVEN YET

This formula has not completed clinical validation. Three of its six ingredients carry authorised EU claims, but none of those claims is about inflammation or your CRP, the EMA does not recognise turmeric for it, and the two-week plan has not been tested by us in a trial. The limit of four courses a year is our own decision. When the plan is tested, the result goes on this page, whatever it says.

Others in the same area

See all 29 formulas  →
Muscle damage (CK)ADAPTBloodworkMuscle damage (CK)Oxidative cardiovascularADAPTHealthy agingOxidative cardiovascularLiver (ALT / AST)ADAPTBloodworkLiver (ALT / AST)Glucose & metabolismADAPTBloodworkGlucose & metabolism

YOU DO NOT PICK YOUR FORMULAS

Your data does.

The questionnaire and your first weeks of data decide which six of the 29 end up in your device. This page exists so you can read what one of them is before that happens.

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Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition. Nothing here replaces a healthcare professional.

Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition.