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Four ingredients for when a blood test puts your LDL cholesterol above 130 mg/dl and you are not on a statin: marine omega-3s, coenzyme Q10, an olive polyphenol and resveratrol, taken with your dinner. It is being reformulated, so what you see here may still change. It is ruled out if you take warfarin or acenocoumarol, and it runs for 12 weeks and ends with a new test, not with a promise.
WHAT IS IN IT
These are the reference doses of the formula, at the full 1.8 ml. Your device pours in steps of 0.2 ml, but the plan on file for this one is the full dose every night for 12 weeks. The formula is being reformulated, and two of these doses sit outside the references in our own file. We say which below.
Normal function of the heart, from 250 mg a day
Included on published evidence. Every EU claim for it was rejected
Protection of blood lipids from oxidative stress, from 5 mg a day
No authorised claim. EFSA rejected its cardiovascular and antioxidant claims
Nine pulses of 0.2 ml, the smallest step the device can serve
No proprietary blends, no "complex" hiding the amounts, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.
No proprietary blends, no bulking agents. If an ingredient is in the bottle it is in this table, with its form and its dose.
THE SCIENCE BEHIND IT
In the EU, only a short list of health claims is authorised. The omega-3s and the olive polyphenol are on it. Coenzyme Q10 and resveratrol had their claims looked at and rejected. Neither of the two claims that do apply says anything about lowering your LDL, and we would rather tell you that than write a sentence that sounds the same for all four.
WHAT WE ARE ALLOWED TO SAY
“EPA and DHA contribute to the normal function of the heart.”
Regulation (EU) 432/2012, for a daily intake of 250 mg. This formula carries 1,500 mg, as re-esterified triglyceride rather than ethyl ester. The claim is about the heart, not about cholesterol, and we do not stretch it to cover your LDL.
Reg. 432/2012 · 250 mg a day minimum · 2 sources on file · 2 with a PMID
WHAT WE ARE ALLOWED TO SAY
Nothing. EFSA rejected every claim put to it, so we make none.
EFSA looked at claims on energy, blood pressure, cholesterol and the protection of lipids from oxidation, among others, and turned them all down. It is here on published work, not on a claim. That is a reason to include it, not a permission to promise anything. The upper limit on file for coenzyme Q10 is 100 mg a day, from the German BfR; this formula alone carries 200 mg, twice that. The 200 mg figure is an internal note in our own ingredient file, aligned with the French ANSES reference, and it is what we hold a whole plan to. The two figures in our file do not agree yet, and we would rather say so than pick the larger one.
EFSA Journal 2010;8(10):1793 · 9 sources on file · 1 with a PMID · not a claim
WHAT WE ARE ALLOWED TO SAY
“Olive oil polyphenols contribute to the protection of blood lipids from oxidative stress.”
Regulation (EU) 432/2012, for a daily intake of 5 mg of hydroxytyrosol and its derivatives. This formula carries 25 mg, from an olive leaf extract with at least 40% hydroxytyrosol. The claim is about protecting blood lipids from oxidation, not about lowering them. No upper limit has been set for it.
Reg. 432/2012 · EFSA novel food opinion 2017 · 2 sources on file · 1 with a PMID
WHAT WE ARE ALLOWED TO SAY
Nothing. EFSA rejected its cardiovascular and antioxidant claims, so we make none.
Its approval as a novel food, up to 150 mg a day for adults, is about safety, not about an effect. Our file also notes that very little of it reaches the blood intact, around 1%. This formula carries 100 mg: our file lists 150 mg as the lowest effective dose and marks this one as reduced for safety. That is a reason to be careful with it, not a permission to promise anything.
EFSA Journal 2010;8(10):1489 · novel food, 150 mg a day · 9 sources on file · 1 with a PMID · claim rejected
HOW IT IS POURED
The full dose of this formula is 1.8 ml, which the device serves as nine pulses of 0.2 ml. For some formulas, your band decides how many. For this one, no wearable marker in our library moves the dose: the plan on file is the full dose every night for 12 weeks, then a new lipid test.
TONIGHT'S POUR
NIGHT, WITH YOUR DINNER
Our file times it to your dinner for two reasons: the triglycerides that follow an evening meal, and the fat that coenzyme Q10 needs to be taken up. The omega-3s and the olive extract dissolve in fat too. Other VION formulas come before a meal. This one rides on it on purpose.
COENZYME Q10 AND RESVERATROL AT NIGHT
Our reference files would place both earlier in the day: some people sleep worse when coenzyme Q10 is taken late, and some report a little extra energy from resveratrol. They sit at dinner here for the fat they need. Our file also suggests splitting coenzyme Q10 doses above 100 mg into two intakes; here the full 200 mg is taken at once, with dinner.
45 ML CARTRIDGE
At 1.8 ml a night it is 25 nights. One 12-week cycle is 84 nights, a little over three cartridges, and the app orders each refill from what you actually took.
HOW IT ENTERS YOUR PLAN
ADAPT is the part of your plan that follows your bloodwork. It goes in when a result is out of range, runs for a fixed period at a fixed dose, and comes out or changes when a new test says so.
Our file writes it for an LDL cholesterol above 130 mg/dl in someone who is not taking a statin. It can also follow Cardiovascular: if your LDL has not responded to that CORE formula after three months, this one is added or takes its place. LDL is not part of the VION blood panel yet, so no blood result triggers it automatically. It can come up from your answer on cholesterol in the questionnaire, and it is confirmed by hand.
84 nights at the full dose, then a new lipid profile: LDL, HDL, triglycerides, non-HDL cholesterol and your omega-3 ratio. Twelve weeks is the usual point to re-check lipids. Nothing about this formula moves inside that window.
The goal on file is an LDL below 100 mg/dl, or below 70 mg/dl if your risk is high. If your LDL has not responded after 12 weeks, the rule on file is a referral to a cardiologist, where a statin can be considered. One note in our file says six months rather than 12 weeks, and that is still being settled.
The cycle can be repeated. The two authorised claims behind this formula are written for ongoing use, so our file sets no required break. We found no yearly limit on file either, so we do not invent one.
SAFETY AND INTERACTIONS
Every pair of ingredients in our library is checked against the others before a plan is built. Inside this formula, the one documented pair, coenzyme Q10 with resveratrol, is marked as combinable at supplement doses and needs no separation. Across your plan, this is what the check watches.
ABOVE THE 100 MG REFERENCE
The upper limit on file for coenzyme Q10 is 100 mg a day, from the German BfR, and this formula alone carries 200 mg, twice that. A separate note in our ingredient file holds a whole plan to 200 mg, in line with the French ANSES reference. Cardiovascular carries the same 200 mg of coenzyme Q10, 1,500 mg of EPA + DHA and 25 mg of hydroxytyrosol, also with dinner. Energy & vitality carries 100 mg of coenzyme Q10 in the morning. Either one would take the total past both figures, so they are checked together before they share a plan. EPA + DHA sits in six of our formulas and the upper limit on file for it is 5,000 mg a day, but it is not one of the seven ingredients our accumulated-limit rule tracks, so that total is not watched automatically yet.
NEVER PAST 150 MG
That formula carries another 100 mg of resveratrol. Together they would reach 200 mg, past the 150 mg a day of its novel food approval, which is the daily total we hold resveratrol to across your plan. Resveratrol is also one of eight ingredients in our library counted as antiplatelet. If your plan would hold two or more, such as the turmeric in three of our formulas, the ginkgo in Cognitive & focus or the vitamin E in Liver (ALT / AST), it is flagged for bleeding risk, and blocked if you are on anticoagulants.
TALK TO A DOCTOR FIRST
Never with warfarin or acenocoumarol: coenzyme Q10 can reduce their effect, and resveratrol adds to the risk of bleeding. Not for pregnancy or breastfeeding, or for anyone under 18. It was written for people who are not on a statin, so if you take one, talk to your doctor first: resveratrol can raise the levels of medicines broken down by the liver enzymes CYP3A4, CYP2C9, CYP2D6 or CYP1A2, such as statins or ciclosporin. Grapefruit raises resveratrol levels the same way, and the data on combining it with immunomodulators are mixed. Talk to a doctor first too if you take any other anticoagulant (such as apixaban or dabigatran), an antiplatelet such as aspirin or clopidogrel, anti-inflammatory painkillers (NSAIDs), or blood pressure or diabetes medication; if you have a bleeding disorder or liver disease; or if you have cancer, a hormone-dependent cancer or are in cancer treatment. Stop it 1–2 weeks before planned surgery. It contains fish and is not suitable for vegans or vegetarians. Tell your doctor about any medicine you take, do not exceed the daily dose, do not use it in place of a varied and balanced diet, and keep it out of reach of young children. The app asks before it ever assigns this one.
WHERE THIS COMES FROM
Regulation (EU) 432/2012 on permitted health claims · EFSA Journal 2010;8(10):1793 on coenzyme Q10 · EFSA Journal 2010;8(10):1489 on resveratrol · EFSA Journal 2016 on the safety of trans-resveratrol as a novel food · EFSA Journal 2017 on the safety of hydroxytyrosol · upper intake references for EPA + DHA, coenzyme Q10 and resveratrol. Every line on this page is tied to one of the 810 sources on file, and 443 of the 9,730 possible ingredient pairs in our library are documented so far.
WHERE IT COMES FROM
Six sources hold up this formula: the regulation that lets us make two of the claims, the EFSA opinions that rejected the claims for coenzyme Q10 and resveratrol, the safety opinions on the resveratrol and the olive extract, and the upper references we measure the doses against.
Reviewed by VION nutrition team · last reviewed 16 September 2026
WHAT IS NOT PROVEN YET
This formula is being reformulated and has not been through clinical validation. Two of its four ingredients carry authorised EU claims, but neither claim is about lowering LDL cholesterol, and the combination has not been tested by us in a trial. Several points are still open: what the reformulation changes, coenzyme Q10 at twice the 100 mg reference on file, resveratrol below the dose our file calls effective, how it combines with Cardiovascular, which carries the same 200 mg of coenzyme Q10, and LDL, which is not yet in our blood panel. When they are settled, and when the formula is tested, the result goes on this page, whatever it says.
YOU DO NOT PICK YOUR FORMULAS
The questionnaire and your first weeks of data decide which six of the 29 end up in your device. This page exists so you can read what one of them is before that happens.
Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition. Nothing here replaces a healthcare professional.
Food supplement. Does not replace a varied diet or a healthy lifestyle. VION does not diagnose or treat any condition.
